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首页> 外文期刊>Biomolecular engineering >Vascular prostheses with controlled release of antibiotics Part 1: Surface modification with cyclodextrins of PET prostheses.
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Vascular prostheses with controlled release of antibiotics Part 1: Surface modification with cyclodextrins of PET prostheses.

机译：控释抗生素的血管假体第1部分：用PET假体的环糊精进行表面修饰。

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摘要

Vascular prostheses were functionalised with the aim to obtain a slow release of antibiotics in order to reduce postoperative infections. The original process that we present in this paper is based on the use of a family of cage molecules named cyclodextrins (CD). These compounds have the ability to form reversible inclusion complexes with drugs such as antibiotics. The aim of this work was to graft CD onto the prosthesis, so that an antibiotic can be bound on it by this inclusion phenomenon, and then be progressively released over a prolonged period by a complex dissociation mechanism. This paper presents the first part of this research program and concerns mainly the study of the functionalization parameters. It presents surface characterization results of the modified prostheses. The PET prostheses were immersed into a solution containing a cross linking agent, cyclodextrins (beta-CD, gamma-CD, HP-beta-CD and HP-gamma-CD) and a catalyst and were padded. Grafting occurred by the mean of a thermofixation step at a temperature comprised between 140 and 180 degrees C. It was observed that the support was permanently modified when the CD polymer that coated the fibres resisted to the final washing process. Grafting rates of 12 wt% in CD polymer could be reached. It was also observed that the fibre coating reaction induced an increase of the permeability of the grafts.
机译：血管假体的功能化旨在获得缓慢释放的抗生素，以减少术后感染。我们在本文中介绍的原始过程是基于使用称为环糊精（CD）的笼状分子家族的使用。这些化合物具有与药物（例如抗生素）形成可逆包合物的能力。这项工作的目的是将CD移植到假体上，以便可以通过这种包涵现象将抗生素结合在其上，然后通过复杂的解离机制在较长的时间内逐步释放。本文介绍了该研究计划的第一部分，主要涉及功能化参数的研究。它显示了改性假体的表面表征结果。将PET假体浸入含有交联剂，环糊精（β-CD，γ-CD，HP-β-CD和HP-γ-CD）和催化剂的溶液中并填充。通过在140至180℃之间的温度下的热固定步骤的平均值发生接枝。观察到，当涂覆纤维的CD聚合物抵抗最终洗涤过程时，载体被永久地改性。 CD聚合物中的接枝率可以达到12 wt％。还观察到纤维涂覆反应引起接枝物的渗透性增加。

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