Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Tr?ger's base derivatives

Jameson D.L.; Field T.; Schmidt M.R.; Destefano A.K.; Stiteler C.J.; Venditto V.J.; Krovic B.; Hoffman C.M.; Ondisco M.T.; Belowich M.E.

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Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Tr?ger's base derivatives

机译：结晶诱导的不对称转化在解析2,8-二取代的Trger碱衍生物的通用可扩展方法中的应用

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A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Tr?ger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Tr?ger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.

机译：通过应用结晶诱导的不对称转化（CIAT），已经获得了一种以63-91％的收率获得2位和2,8位双取代的Trger碱（TB）衍生物的克级分辨率的通用方法。分离的TB衍生物的对映体比例为99.1：0.9至> 99.5：0.5。在Trger的基础化合物中，有四种具有合成价值的溴和碘衍生物。

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《The Journal of Organic Chemistry》 |2013年第22期|共7页
作者
Jameson D.L.; Field T.; Schmidt M.R.; Destefano A.K.; Stiteler C.J.; Venditto V.J.; Krovic B.; Hoffman C.M.; Ondisco M.T.; Belowich M.E.;
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正文语种 eng
中图分类有机化学;
关键词
Application; crystallization-induced; asymmetric transformation;

机译：应用;结晶诱导;不对称转变;

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1. Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Tr?ger's base derivatives [J] . Jameson D.L., Field T., Schmidt M.R., The Journal of Organic Chemistry . 2013,第22期

机译：结晶诱导的不对称转化在解析2,8-二取代的Trger碱衍生物的通用可扩展方法中的应用
2. Synthesis of Versatile Nonsymmetric Amine- and Boron-Functionalized Tr?ger's Base Derivatives, Including a Tr?ger's Base Amino Acid [J] . Amanda L. Whiting, Krystyn I. Dubicki, Fraser Hof European journal of organic chemistry . 2013,第30期

机译：多功能非对称胺和硼官能化的Trger碱基衍生物的合成，包括Trger碱基氨基酸
3. Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-beta-carbolines in water [J] . Meng Tian-Zhuo, Shi Xiao-Xin, Qu Hui-Ya, RSC Advances . 2017,第75期

机译：在水中1,3-二取代 - 四氢β-咔啉的高度非映选择性结晶诱导的不对称转化
4. Subsea Wellhead System Verification Analysis Methodology for HPHT Applications per API TR 1PER15K-1 and API 17TR8 [C] . Stephen A. Perales, Jim T. Kaculi American Institute of Mining, Metallurgical and Petroleum Engineers;American Institute of Chemical Engineers;American Association of Petroleum Geologists;Offshore Technology Conference . 2015

机译：根据API TR 1PER15K-1和API 17TR8进行HPHT应用的海底井口系统验证分析方法
5. Asymmetric synthesis of all-carbon alpha-aryl quaternary carbonyl compounds by palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) and their application to the synthesis of biologically important 3,3 '-disubstituted oxindole and alpha-disubstituted quaternary beta-lactone frameworks. [D] . Asad, Md. Sharif A. 2015

机译：钯催化的不对称烯丙基烷基化反应（Pd-AAA）的全碳α-芳基季羰基化合物的不对称合成及其在生物学上重要的3,3'-二取代的羟吲哚和α-二取代的季铵β-内酯骨架的合成中。
6. Circularly polarized luminescent systems fabricated by Trögers base derivatives through two different strategies [O] . Cheng Qian, Yuan Chen, Qian Zhao, 2021

机译：通过两种不同的策略由Tröger的基础衍生物制造的圆偏振发光系统
7. Asymmetric Strecker Synthesis of α-Amino Acids via a Crystallization-Induced Asymmetric Transformation Using (R)-Phenylglycine Amide as Chiral Auxiliary [O] . Boesten, Wilhelmus H.J., Seerden, Jean-Paul G., Lange, Ben de, 2001

机译：（R）-苯基甘氨酸酰胺作为手性助剂通过结晶诱导的不对称转化进行不对称Strecker合成α-氨基酸
8. Systematic Studies of Molecular Vibrational Anharmonicity and Vibration-Rotation Interaction by Self-Consistent-Field Higher Derivative Methods: Applications to Asymmetric and Symmetric Top and Linear Polyatomic Molecules [R] . Clabo, D. A. 1987

机译：自洽场高导数方法对分子振动非谐性和振动 - 旋转相互作用的系统研究：非对称和对称顶部和线性多原子分子的应用

Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Tr?ger's base derivatives

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