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首页> 外文期刊>The Journal of Prosthetic Dentistry >Susceptibility of Candida albicans isolates from the oral cavities of HIV-positive patients to histatin-5.
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Susceptibility of Candida albicans isolates from the oral cavities of HIV-positive patients to histatin-5.

机译：HIV阳性患者口腔中的白色念珠菌对组蛋白5的敏感性。

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STATEMENT OF PROBLEM: Oral surfaces, including the denture-fitting surface, may serve as a reservoir for disseminated candidal infections, particularly in immunocompromised hosts such as patients with AIDS. Histatins are a group of small, cationic antifungal peptides present in human saliva. There is limited information on the antifungal activity of peptides against Candida albicans isolates from HIV-positive patients. PURPOSE: This study investigated the fungicidal effects of histatin-5 against oral isolates of C. albicans from HIV-positive and HIV-negative patients. MATERIAL AND METHODS: An isolate of C. albicans from each of 2 HIV-positive patients (both male) and 3 HIV-negative patients (2 male and 1 female) was obtained. American Type Culture Collection 90028 served as a reference strain. All isolates were identified with sugar assimilation tests and the germ tube test. Fungicidal assays were performed on exponential C. albicans cells in the presence or absence of 0.315 to 50 microm of histatin-5.Numerical data were subjected to 1-way analysis of variance and Tukey's multiple range test (P<.05). RESULTS: Histatin-5 (50 microm) killed more than 95% of C. albicans isolates from HIV-negative patients and more than 90% of isolates from the reference strain. The same treatment induced 75.3% and 66.1% loss of viability in C. albicans isolates taken from HIV-positive patients (A1 and A2 cells, respectively). The difference between the fungicidal effects in the HIV-positive and HIV-negative groups was significant. (P<.05). CONCLUSION: Within the limited population of this study, C. albicans isolates from the oral cavities of HIV-positive patients were less sensitive to histatin-5 than oral isolates from HIV-negative patients.
机译：问题陈述：包括义齿贴合表面在内的口腔表面可作为散播性念珠菌感染的储存库，尤其是在免疫功能低下的宿主（如艾滋病患者）中。 Histatins是人类唾液中存在的一组小型阳离子抗真菌肽。关于该肽对来自HIV阳性患者的白色念珠菌分离物的抗真菌活性的信息有限。目的：本研究调查了组蛋白5对来自HIV阳性和HIV阴性患者的白色念珠菌口服分离株的杀菌作用。材料与方法：从2名HIV阳性患者（均为男性）和3名HIV阴性患者（分别为2名男性和1名女性）中分离出白色念珠菌。美国典型培养物保藏中心90028用作参考菌株。所有分离物均通过糖同化试验和胚芽管试验鉴定。在存在或不存在0.315至50微米的组蛋白5的情况下，对指数型白色念珠菌细胞进行了杀真菌试验。对数值数据进行了方差分析和Tukey多范围检验（P <0.05）。结果：Histatin-5（50微米）杀死了超过95％的来自HIV阴性患者的白色念珠菌分离株，以及超过90％的来自参考菌株的分离株。在从HIV阳性患者（分别为A1和A2细胞）获取的白色念珠菌分离物中，相同的处理导致75.3％和66.1％的活力丧失。 HIV阳性和HIV阴性组的杀真菌效果之间存在显着差异。 （P <.05）。结论：在该研究的有限人群中，HIV阳性患者口腔中的白色念珠菌分离株对HIV-1的敏感性低于HIV阴性患者的口腔分离株。

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