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首页> 外文期刊>The Journal of Prosthetic Dentistry >Prosthodontic treatment of a patient taking nitrogen-containing bisphosphonates to preserve the integrity of the epithelial attachment: A clinical report
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Prosthodontic treatment of a patient taking nitrogen-containing bisphosphonates to preserve the integrity of the epithelial attachment: A clinical report

机译：服用含氮双膦酸盐的患者的修复治疗以保持上皮附着的完整性：临床报告

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摘要

Osteonecrosis of the jaw has been identified in recent years as an unfortunate potential side effect for patients taking nitrogen-containing bisphosphonates. Many authors have attempted unsuccessfully to elucidate the mechanism behind this drug-induced malady, leaving dentists with unclear guidelines on how to treat these patients. Recent literature suggests a threshold-related impairment of epithelial cell migration over bone. A conservative, non-invasive approach aimed at preserving the epithelial attachment in a patient on a long-term oral alendronate protocol is described. The advantage of this approach is to prevent a highly destructive bone degenerative process that does not have a clear and predictable treatment protocol.
机译：近年来，颌骨坏死被确定为服用含氮双膦酸盐类药物的患者的潜在潜在副作用。许多作者试图阐明这种药物引起的疾病的机制均未成功，使牙医对如何治疗这些患者缺乏明确的指导方针。最近的文献提出了阈值相关的上皮细胞在骨上迁移的损伤。描述了一种保守的，非侵入性的方法，旨在通过长期口服阿仑膦酸盐方案在患者体内维持上皮附着。这种方法的优点是可以防止没有明确和可预测的治疗方案的高度破坏性的骨骼退化过程。

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