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首页> 外文期刊>The Journal of Urology >Is quality of life different for men with erectile dysfunction and prostate cancer compared to men with erectile dysfunction due to other causes? Results from the ExCEED data base.
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Is quality of life different for men with erectile dysfunction and prostate cancer compared to men with erectile dysfunction due to other causes? Results from the ExCEED data base.

机译：与其他原因导致的勃起功能障碍男性相比，勃起功能障碍和前列腺癌男性的生活质量是否有所不同？来自ExCEED数据库的结果。

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PURPOSE: To our knowledge the relationship between the underlying etiology of erectile dysfunction and its impact on health related quality of life has not been studied. Such a study is important for men with prostate cancer, as the potential negative quality of life impact of erectile dysfunction may affect clinical decision making in newly diagnosed disease. We compare health related quality of life in impotent men with prostate cancer to that of impotent men without prostate cancer using the Exploratory and Comprehensive Evaluation of Erectile Dysfunction (ExCEED, TAP Pharmaceutical Products, Inc., Lake Forest, Illinois) data base, which is a multicenter, observational disease registry of men with erectile dysfunction. MATERIALS AND METHODS: The cohort included 168 men in ExCEED who had baseline health related quality of life measurement. Of these men 47 reported a history of prostate cancer while 121 did not. Appropriate univariate and multivariate analyses were performed comparing health related quality of life outcomes between impotent men with and without prostate cancer. RESULTS: Men with erectile dysfunction and prostate cancer had worse sexual self-efficacy, erectile function, intercourse satisfaction and orgasmic function than those with erectile dysfunction without prostate cancer (all p <0.001). However, men with erectile dysfunction and prostate cancer experienced less psychological impact of erectile dysfunction on sexual experience (p = 0.05) and emotional life (p = 0.03) than those with erectile dysfunction without prostate cancer. The findings regarding the psychological impact of erectile dysfunction persisted in multivariate linear regression models. CONCLUSIONS: Men with erectile dysfunction and prostate cancer appear to have better disease specific health related quality of life than those with erectile dysfunction and no history of prostate cancer. This finding has important ramifications for clinicians when counseling patients newly diagnosed with prostate cancer and also when treating patients who present with erectile dysfunction of various etiologies.
机译：目的：据我们所知，尚未研究勃起功能障碍的潜在病因与其对健康相关生活质量的影响之间的关系。这项研究对男性前列腺癌非常重要，因为勃起功能障碍可能对生活质量造成负面影响，可能会影响新诊断疾病的临床决策。我们使用勃起功能障碍的探索性和综合评估（ExCEED，TAP Pharmaceutical Products，Inc.，Lake Forest，伊利诺伊州）数据库来比较患有前列腺癌的无症状男性与没有前列腺癌的无症状男性的健康相关生活质量，这是勃起功能障碍男性的多中心观察性疾病登记册。材料与方法：该队列包括168名Exceed男性患者，这些患者具有与基线健康相关的生活质量测量。在这些男性中，有47名报告有前列腺癌病史，而121名没有。进行了适当的单变量和多变量分析，比较了有无前列腺癌的无能为力的男性与健康相关的生活质量。结果：与没有前列腺癌的勃起功能障碍男性相比，患有勃起功能障碍和前列腺癌的男性的性自我效能，勃起功能，性交满意度和性高潮功能较差（所有p <0.001）。然而，与没有前列腺癌的勃起功能障碍男性相比，勃起功能障碍和前列腺癌男性对性经历（p = 0.05）和情感生活（p = 0.03）的心理影响较小。关于勃起功能障碍的心理影响的研究结果在多元线性回归模型中仍然存在。结论：与勃起功能障碍且无前列腺癌病史的男性相比，与勃起功能障碍和前列腺癌男性相比，其与疾病相关的健康相关的生活质量更高。这一发现对于临床医生在咨询刚被诊断出患有前列腺癌的患者以及治疗患有各种病因的勃起功能障碍的患者时具有重要意义。

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