...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Telomerase regulation in hematological cancers: a matter of stemness?
【24h】

Telomerase regulation in hematological cancers: a matter of stemness?

机译：血液癌症中端粒酶的调控：干吗？

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human telomerase is a nuclear ribonucleoprotein enzyme complex that catalyzes the synthesis and extension of telomeric DNA. This enzyme is highly expressed and active in most malignant tumors while it is usually not or transiently detectable in normal somatic cells, suggesting that it plays an important role in cellular immortalization and tumorigenesis. As most leukemic cells are generally telomerase-positive and have often shortened telomeres, our understanding of how telomerase is deregulated in these diseases could help to define novel therapies targeting the telomere/telomerase complex. Nonetheless, considering that normal hematopoietic stem cells and some of their progeny do express a functional telomerase, it is tempting to consider such an activity in leukemias as a sustained stemness feature and important to understand how telomere length and telomerase activity are regulated in the various forms of leukemias.
机译：人端粒酶是核糖核酸核酶复合物，可催化端粒DNA的合成和延伸。该酶在大多数恶性肿瘤中高度表达并具有活性，而在正常的体细胞中通常不能或不能瞬时检测到，这表明它在细胞永生化和肿瘤发生中起重要作用。由于大多数白血病细胞通常是端粒酶阳性的，并且端粒通常会缩短，因此我们对端粒酶在这些疾病中如何失调的理解可能有助于确定靶向端粒/端粒酶复合物的新疗法。尽管如此，考虑到正常的造血干细胞及其某些后代确实表达了功能性端粒酶，因此将白血病中的这种活性视为持续的干性特征并试图理解端粒长度和端粒酶活性如何以各种形式被调节很重要。白血病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号