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首页> 外文期刊>The journal of sexual medicine >Effect of a local delivery of triiodothyronine (T3) within neuroregenerative guide on recovery of erectile function in a rat-model of cavernous nerve injury.
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Effect of a local delivery of triiodothyronine (T3) within neuroregenerative guide on recovery of erectile function in a rat-model of cavernous nerve injury.

机译：在大鼠神经性海绵状神经损伤模型中，在神经再生引导剂中局部递送三碘甲状腺素（T3）对勃起功能恢复的影响。

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INTRODUCTION: A promoting effect of thyroid hormones has been established on the maturation of central and peripheral nervous systems. However, effects on autonomic nerves have never been experimentally investigated. AIM: To assess the effect of a local treatment combining silicone guides and local administration of Triiodothyronine (T3) on the erectile function and the histological neuroregeneration of crushed cavernous nerves (CNs) in rats. METHODS: Forty-five rats were divided into five equal groups: SHAM surgery, guide without crush, crush, crush + guide, crush + guide + T3. All surgical procedures were bilateral. CNs were crushed with microvascular bulldog clamp of 100 g/cm(2). A silicone guide was placed around the nerves. The guides were filled with T3 neuroregenerative solution. MAIN OUTCOME MEASURES: Erectile function was assessed 10 weeks post-operatively. Intra-cavernous pressure (ICP) and mean arterial pressure (MAP) were monitored during electrical stimulation of CNs at various frequencies. The main outcome was hardness of erection defined as DeltaICP/MAP. Fluorescent immunohistochemical analysis of CNs was performed to assess regeneration of nerves morphologically. RESULTS: Electrophysiological data showed increased recovery of erectile function in the group with guide + T3 neuroregenerative solution compared with the empty guide. Immunohistochemical analysis of cavernous nerves demonstrated in morphology that regenerated axons were straighter in nerves with guide and more regular if guides had been filled with T3. CONCLUSION: The use of guides prevented axonal sprouting, facilitated functional neuroregeneration and enabled a local delivery of thyroid hormones. Triiodothyronine improved neuroregeneration and recovery of erectile function after a nerve-sparing-like injury in a rat model.
机译：简介：甲状腺激素对中枢神经系统和周围神经系统的成熟具有促进作用。然而，从未通过实验研究对自主神经的影响。目的：评估有机硅引导剂和三碘甲状腺素（T3）局部给药对大鼠勃起功能和海绵状神经（CNs）的组织神经再生的影响。方法：将四十五只大鼠分为五个相等的组：SHAM手术，无压迫引导，压迫，压迫+引导，压迫+引导+ T3。所有手术程序均为双侧。用100 g / cm（2）的微血管斗牛犬钳压碎CN。将硅树脂导向器放置在神经周围。指南充满了T3神经再生溶液。主要观察指标：术后10周评估勃起功能。在不同频率的CNs电刺激过程中，监测了海绵体内压力（ICP）和平均动脉压（MAP）。主要结果是勃起硬度定义为DeltaICP / MAP。对CNs进行荧光免疫组织化学分析，以形态学评估神经的再生。结果：电生理数据显示，与空白指南相比，指南+ T3神经再生溶液组的勃起功能恢复增加。形态学证明海绵状神经的免疫组织化学分析表明，在指导下，再生轴突在神经中更直，如果在指导中充满T3，则轴突更规则。结论：使用指南可防止轴突发芽，促进功能性神经再生并能够局部递送甲状腺激素。三碘甲状腺素改善了大鼠模型中神经保护样损伤后的神经再生和勃起功能的恢复。

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