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首页> 外文期刊>The journal of sexual medicine >Angiotensin-Converting Enzyme Polymorphism and Erectile Dysfunction Complaints in the Brazilian Population
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Angiotensin-Converting Enzyme Polymorphism and Erectile Dysfunction Complaints in the Brazilian Population

机译：巴西人群中血管紧张素转换酶多态性和勃起功能障碍的投诉。

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Introduction. Angiotensin-converting enzyme (ACE) is the major regulator of circulatory homeostasis. An insertion/deletion (I/D) polymorphism in the ACE gene has been associated with marked differences in serum ACE levels and with various cardiovascular diseases. Limited and conflicting data have been published on the influence of this genetic variant on the pathophysiology of erectile dysfunction (ED). Aim. To evaluate a potential association between ACE gene polymorphism and ED complaints in a population-based sample in Sao Paulo, Brazil. Main Outcome Measures. The prevalence of ED complaints was estimated according to previously validated 8 item questionnaire. Methods. A total of 449 men were enrolled in the Epidemiologic Sleep Study and answered an 8-item questionnaire to ascertain sexual performance/ED and satisfaction. ACE gene polymorphism were genotyped using a standard polymerase chain reaction method. Results. No significant case-control difference was observed for the ACE gene I/D polymorphism either by genotype or allele-wise. Because age is a significant risk factor for ED complaints in our sample, we carried out analyses stratifying the sample by age group. The ID and II genotypes were significantly more frequent in ED complaint cases (88.9%) compared with controls (57.1%) in the men between 40 and 55 years of age. The frequency of the I allele was also significantly higher in individuals complaining of ED (66.7%) compared with men with no complaints (39.0%) (odds ratio = 3.12; 95% confidence interval = 1.48-6.59). Correction for potential confounding variables, including genetic ancestry, did not affect the strength of the association. Conclusions. The findings of the present study suggest that the I/D polymorphism or another variant in close linkage disequilibrium with it may play a role in the development of ED in a specific age group and provides progress towards the understanding of the interaction between genetic factors and the risk of ED.
机译：介绍。血管紧张素转换酶（ACE）是循环稳态的主要调节剂。 ACE基因中的插入/缺失（I / D）多态性与血清ACE水平的显着差异以及各种心血管疾病有关。关于这种遗传变异对勃起功能障碍（ED）病理生理学影响的有限且矛盾的数据已经发表。目标。在巴西圣保罗的人群样本中评估ACE基因多态性与ED投诉之间的潜在关联。主要观察指标。 ED投诉的发生率是根据之前已验证的8项问卷进行估算的。方法。共有449名男性参加了流行病学睡眠研究，并回答了8项问卷，以确定性行为/ ED和满意度。使用标准聚合酶链反应方法对ACE基因多态性进行基因分型。结果。 ACE基因I / D多态性无论是基因型还是等位基因均未观察到明显的病例对照差异。由于年龄是我们样本中ED投诉的重要风险因素，因此我们进行了按年龄组对样本进行分层的分析。在40到55岁的男性中，ED投诉病例中ID和II基因型的发生率（88.9％）显着高于对照组（57.1％）。与没有抱怨的男性（39.0％）相比，抱怨ED的个体中I等位基因的频率也显着更高（66.7％）（优势比= 3.12; 95％的置信区间= 1.48-6.59）。对潜在混杂变量（包括遗传血统）的校正不会影响关联的强度。结论。本研究的发现表明，I / D多态性或与其紧密连锁不平衡的另一种变异可能在特定年龄段的ED的发展中发挥作用，并为了解遗传因素与人类之间的相互作用提供了进展。 ED的风险。

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