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首页> 外文期刊>The journal of sexual medicine >Coronary Phenotypes in Patients with Erectile Dysfunction and Silent Ischemic Heart Disease: A Pilot Study
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Coronary Phenotypes in Patients with Erectile Dysfunction and Silent Ischemic Heart Disease: A Pilot Study

机译：勃起功能障碍和沉默性缺血性心脏病患者的冠状动脉表型：一项初步研究。

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Introduction. Accumulated evidence shows that erectile dysfunction (ED) may be a precursor of coronary artery disease (CAD). Aims. The purpose of this study was to explore the differences in coronary phenotypes between patients with ED and patients with angina pectoris. Methods. The study enrolled 30 ED patients (study group) and 120 age-matched angina patients who had no ED (control group). All patients had angiographically documented CAD. Main Outcome Measures. The differences in demographic characteristics, biochemical profiles and coronary characteristics between the study and control groups were compared. Results. Diabetes mellitus (DM) and obesity denned by body mass index were more common in the study group than in the control group. The mean number of lesions and mean number of vessels with evidence of CAD were significantly different between the study and control groups (2.3 +- 0.1 vs. 2.2 +- 0.1, P< 0.001; 2.0 +- 0.2 vs. 1.8 +- 0.1, P< 0.001). The distribution of vessel involvement was similar between the groups, except for more common involvement of the ramus in the study group. There were no differences in distribution of lesion sites between the two groups. The control group had a higher percentage of type A stenotic lesions than the study group (16.3% vs. 2.9%, P = 0.004). Significant differences were also observed in type C lesions (52.9% in study group vs. 38.0% in control group, P = 0.026). Fewer calcified, irregular, and bifurcated lesions were present in the study group compared to control. Conclusions. This study documented coronary phenotypes in ED patients without symptomatic CAD. Although the artery size hypothesis and ED had well been thought to be a precursor of CAD, the severity of coronary lesions in these patients was not more benign than that observed in angina pectoris patients who have no ED.
机译：介绍。累积的证据表明，勃起功能障碍（ED）可能是冠状动脉疾病（CAD）的前兆。目的这项研究的目的是探讨ED患者和心绞痛患者冠状动脉表型的差异。方法。该研究招募了30名ED患者（研究组）和120名没有ED的年龄匹配型心绞痛患者（对照组）。所有患者均具有血管造影记录的CAD。主要观察指标。比较研究组和对照组在人口统计学特征，生化特征和冠状动脉特征上的差异。结果。由体重指数确定的糖尿病和肥胖在研究组中比在对照组中更为常见。研究组和对照组之间的平均病变数和具有CAD证据的平均血管数显着不同（2.3 +-0.1与2.2 +-0.1，P <0.001; 2.0 +-0.2与1.8 +-0.1， P ＜0.001）。各组间血管受累的分布相似，但在研究组中支气管更常见。两组之间病变部位的分布没有差异。对照组的A型狭窄病变百分比高于研究组（16.3％比2.9％，P = 0.004）。在C型病变中也观察到了显着差异（研究组为52.9％，对照组为38.0％，P = 0.026）。与对照组相比，研究组中钙化，不规则和分叉病变更少。结论。这项研究记录了没有症状性CAD的ED患者的冠状动脉表型。尽管动脉大小假说和ED被认为是CAD的先兆，但这些患者中冠状动脉病变的严重程度并不比没有ED的心绞痛患者良性。

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