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首页> 外文期刊>The journal of sexual medicine >Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction.
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Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction.

机译：勃起功能障碍患者的严重抑郁症状和心血管风险。

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INTRODUCTION: Erectile dysfunction (ED) and mood depression are often associated and both are correlated with an increased risk of cardiovascular morbidity and mortality. AIM: The aim of the present study is to explore biological and clinical correlates of depressive symptomatology in a sample of men consulting for sexual dysfunction and to verify possible associations between depressive symptoms and incidence of major cardiovascular events (MACE). METHODS: A consecutive series of 2,303 male patients attending the Outpatient Clinic for sexual dysfunction was retrospectively studied. A subset of the previous sample (N= 1,687) was enrolled in a longitudinal study. All patients were investigated using a Structured Interview on Erectile Dysfunction (SIEDY), composed of 3 scales which explore organic, relational and intra-psychic components of ED. MHQ-D scoring from Middlesex Hospital Questionnaire (MHQ) was used as a putative marker of depressive symptoms. MAIN OUTCOME MEASURES: Information on MACE was obtained through the City of Florence Registry Office. RESULTS: We found a positive relationship between MHQ-D score and a progressive impairment in obtaining an erection hard enough for penetration, even after adjusting for confounding factors. Moreover, we observed positive relationships between MHQ-D score and the three pathogenetic domains underlying ED. When the longitudinal subset was evaluated, during a mean follow-up of 4.3+/-2.6 years, 139 MACE, 15 of which were fatal, were observed. Unadjusted incidence of MACE was significantly associated with baseline depressive symptoms. When the presence of severe depressive symptoms were introduced in a Cox regression model, along with the arteriogenic ED and partner's hypoactive sexual desire, after adjusting for age, Chronic Diseases Score, and SigmaMHQ (a broader index of psychopathology), severe depressive symptomatology was independently associated with a higher incidence of MACE. CONCLUSION: Depressive symptomatology constitutes an independent risk factor for cardiac morbidity and mortality in men with ED.
机译：简介：勃起功能障碍（ED）和情绪低落经常相关，并且两者都与心血管疾病发病率和死亡率增加相关。目的：本研究的目的是探讨咨询性功能障碍的男性样本中抑郁症状的生物学和临床相关性，并验证抑郁症状与主要心血管事件（MACE）发生率之间的可能联系。方法：回顾性研究了连续2,303例因性功能障碍而就诊于门诊诊所的男性患者。纵向研究中纳入了先前样本的一部分（N = 1,687）。所有患者均通过对勃起功能障碍的结构化访谈（SIEDY）进行调查，该访谈由3个量表组成，探讨了ED的器质性，关系性和精神内因素。来自米德尔塞克斯医院问卷调查（MHQ）的MHQ-D评分被用作抑郁症状的推定指标。主要观察指标：关于MACE的信息是通过佛罗伦萨市登记处获得的。结果：我们发现MHQ-D评分与进行性损害之间的正相关关系，即使经过混杂因素的调整也难以获得足够的穿透力。此外，我们观察到MHQ-D评分与ED的三个致病域之间存在正相关。当评估纵向子集时，平均随访时间为4.3 +/- 2.6年，观察到139例MACE，其中15例是致命的。未经调整的MACE发生率与基线抑郁症状显着相关。当在年龄，慢性病评分和SigmaMHQ（更广泛的心理病理学指标）进行调整后，将严重抑郁症状的出现，Cero回归模型，动脉源性ED和伴侣的性欲减退一起引入时，严重抑郁症状是独立的与MACE发生率更高相关。结论：抑郁症状是ED患者心脏发病和死亡的独立危险因素。

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