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首页> 外文期刊>The journal of sexual medicine >Erectile Dysfunction and Risk of Clinical Cardiovascular Events: A Meta-Analysis of Seven Cohort Studies
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Erectile Dysfunction and Risk of Clinical Cardiovascular Events: A Meta-Analysis of Seven Cohort Studies

机译：勃起功能障碍和临床心血管事件的风险：对七个队列研究的荟萃分析

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Introduction. For many years, erectile dysfunction (ED) has been considered as a complication of cardiovascular disease (CVD) or regarded as a late consequence of generalized arterial disease. However, a growing body of evidence suggests that ED is an early manifestation of atherosclerosis and a precursor to systemic vascular disease. Aim. We conducted a meta-analysis to evaluate the association between ED and the risk of CVD events. Methods. Relevant studies published between January 1966 and September 2009 were identified by searching Medline, Embase, and The Cochrane Library. Studies were selected using a prior defined criteria. The strength of the relationship between ED and CVD events was assessed by adjusted relative risks (RRs). Main Outcome Measures. The adjusted RRs of CVD events. Results. A total of 45,558 participants from seven cohort studies (eight full-text articles) were identified in this meta-analysis. The studies provided adjusted RRs estimates for ED subjects comparing with health subjects, leading to a pooled adjusted RR of 1.47 (95% confidence interval [CI], 1.29-1.66, P< 0.001; P for heterogeneity = 0.152; I~2 = 36.2%) for CVD events. The risks of CVD, all-cause mortality and myocardial infarction were 1.41 (95% CI, 1.22-1.64 P< 0.001), 1.23 (95% CI, 1.02-1.48; P = 0.034), and 1.43 (95% CI, 1.10-1.85 P= 0.007), respectively. The overall adjusted RR decreased significant from 1.63 (<7 years) to 1.37 (>=7 years) along with the elongation of follow-up. Conclusions. There is evidence of an increased risk of CVD events for patients with ED. Patients who are discovered to have ED are supposed to be thoroughly assessed for cardiovascular risk and occult systemic vascular disease.
机译：介绍。多年来，勃起功能障碍（ED）被认为是心血管疾病（CVD）的并发症或被认为是广义动脉疾病的晚期后果。但是，越来越多的证据表明，ED是动脉粥样硬化的早期表现，是全身血管疾病的先兆。目标。我们进行了荟萃分析，以评估ED与CVD事件风险之间的关联。方法。通过搜索Medline，Embase和The Cochrane Library，确定了1966年1月至2009年9月之间发表的相关研究。使用预先定义的标准选择研究。 ED和CVD事件之间关系的强度通过调整后的相对风险（RR）进行评估。主要观察指标。 CVD事件的调整后RR。结果。这项荟萃分析确定了来自七个队列研究（八篇全文）的总共45,558名参与者。研究提供了与健康受试者相比，ED受试者的校正后RR估计值，导致校正后校正后的RR为1.47（95％置信区间[CI]，1.29-1.66，P <0.001;异质性的P = 0.152; I〜2 = 36.2 ％）用于CVD事件。 CVD，全因死亡率和心肌梗塞的风险分别为1.41（95％CI，1.22-1.64 P <0.001），1.23（95％CI，1.02-1.48; P = 0.034）和1.43（95％CI，1.10） -1.85 P = 0.007）。随着随访时间的延长，总体调整后的RR从1.63（<7年）显着下降到1.37（> = 7年）。结论。有证据表明ED患者发生CVD事件的风险增加。被发现患有ED的患者应该被彻底评估其心血管风险和隐匿性系统性血管疾病。

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