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首页> 外文期刊>The journal of sexual medicine >Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy.
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Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy.

机译：激素治疗之前和期间，男性和男性至女性变性者之间在空间认知方面的神经影像学差异。

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INTRODUCTION: Neuropsychological abnormalities in transsexual patients have been reported in comparison with subjects without gender identity disorder (GID), suggesting differences in underlying neurobiological processes. However, these results have not consistently been confirmed. Furthermore, studies on cognitive effects of cross-sex hormone therapy also yield heterogeneous results. AIM: We hypothesized that untreated transsexual patients differ from men without GID in activation pattern associated with a mental rotation task and that these differences may further increase after commencing of hormonal treatment. METHOD: The present study investigated 11 male-to-female transsexual (MFTS) patients prior to cross-sex hormone therapy and 11 MFTS patients during hormone therapy in comparison with healthy men without GID. Using functional magnetic resonance imaging at 3-Tesla, a mental rotation paradigm with proven sexual dimorphism was applied to all subjects. Data were analyzed with SPM5. MAIN OUTCOME MEASURES: Patterns of brain activation associated with a mental rotation task. RESULTS: The classical mental rotation network was activated in all three groups, but significant differences within this network were observed. Men without GID exhibited significantly greater activation of the left parietal cortex (BA 40), a key region for mental rotation processes. Both transsexual groups revealed stronger activation of temporo-occipital regions in comparison with men without GID. CONCLUSIONS: Our results confirmed previously reported deviances of brain activation patterns in transsexual men from men without GID and also corroborated these findings in a group of transsexual patients receiving cross-sex hormone therapy. The present study indicates that there are a priori differences between men and transsexual patients caused by different neurobiological processes or task-solving strategies and that these differences remain stable over the course of hormonal treatment.
机译：简介：据报道，与没有性别认同障碍（GID）的受试者相比，变性患者的神经心理异常，表明潜在的神经生物学过程存在差异。但是，这些结果尚未得到一致确认。此外，对性交激素疗法的认知作用的研究也得出了异类结果。目的：我们假设未经治疗的变性患者与没有GID的男性在与精神旋转任务相关的激活方式上有所不同，并且这些差异在荷尔蒙治疗开始后可能会进一步增加。方法：与没有GID的健康男性相比，本研究调查了11例跨性别激素治疗前的男女变性（MFTS）患者和11激素治疗期间的MFTS患者。使用3-Tesla的功能磁共振成像技术，将具有证实的性二态性的心理旋转范例应用于所有受试者。用SPM5分析数据。主要观察指标：与精神旋转任务有关的大脑激活方式。结果：在所有三个组中都激活了经典的心理旋转网络，但是在该网络中观察到了显着差异。没有GID的男性表现出明显更大的左侧顶叶皮层（BA 40）激活，这是精神旋转过程的关键区域。与没有GID的男性相比，这两个变性人群均显示出颞枕区域的激活更强。结论：我们的研究结果证实了先前报道的变性人中没有GID的男性大脑激活模式的下降，也证实了一群接受跨性激素疗法的变性患者的这些发现。本研究表明，男性和变性患者之间存在先天差异，这是由不同的神经生物学过程或任务解决策略引起的，并且这些差异在激素治疗过程中保持稳定。

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