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首页> 外文期刊>The journal of sexual medicine >The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction.
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The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction.

机译：睾丸激素联合PDE5抑制剂对患有性功能障碍的女性的认知，情感和生理性功能的影响。

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INTRODUCTION: Women with female sexual dysfunction have a reduced sensitivity to sexual stimuli. Activation of central mechanisms may open a window for phosphodiesterase type 5 inhibitors (PDE5) to be effective; as a consequence, the combination of testosterone and a PDE5 inhibitor will restore sexual function. AIM: To demonstrate that the combination of testosterone and vardenafil will increase the sensitivity for sexual stimuli and will improve the desire and arousal components of the sexual response. Methods. In a double-blind randomly assigned placebo-controlled crossover design, 28 women with desire and/or arousal disorder underwent four different drug treatments on four separate experimental days. A masked version of the emotional Stroop task with sexual and nonsexual words was used to measure sensitivity for sexual content. Neutral and erotic film fragments were used to determine genital-physiological and subjective reactions. MAIN OUTCOME MEASURES: A masked version of the emotional Stroop task, vaginal pulse amplitude. For subjective measurement, responses were collected continuously with a lever and two self-report measures were used. RESULTS: In two subgroups, which were differentiated on the basis of their initial preconscious attentional bias for sexual cues, a different sexual response profile was found. In an initially low-attention group, preconscious attentional bias for sexual cues increased under the testosterone condition. In these women, the combination of testosterone and vardenafil caused an improvement in genital response and subjective indices of sexual functioning. In the group that had initially a high attention for sexual cues, preconscious attentional bias for sexual cues decreased under the condition of testosterone. In these women, the combination of testosterone and vardenafil had no effect on any of the indices of their sexual functioning. CONCLUSION: In women suffering from low sexual desire-associated with low attention for sexual cues-the combination of testosterone and vardenafil may be a promising new treatment.
机译：简介：患有女性性功能障碍的女性对性刺激的敏感性降低。激活中枢机制可能为5型磷酸二酯酶抑制剂（PDE5）发挥作用打开一扇窗。结果，睾丸激素和PDE5抑制剂的组合将恢复性功能。目的：证明睾丸激素和伐地那非的组合将增加对性刺激的敏感性，并改善性反应的欲望和唤醒成分。方法。在双盲随机分配的安慰剂对照交叉设计中，对28位有欲望和/或唤醒障碍的妇女在四个单独的实验日进行了四种不同的药物治疗。带有性和非性词的带情感Stroop任务的蒙版版本用于衡量对性内容的敏感性。中性和色情电影片段被用来确定生殖器生理和主观反应。主要观察指标：情绪化Stroop任务的掩盖版本，阴道搏动幅度。对于主观测量，使用杠杆连续收集响应，并使用两个自我报告测量。结果：在两个亚组中，根据他们对性暗示的最初的先知性注意力偏见进行了区分，发现了不同的性反应特征。在最初的注意力不足组中，在睾丸激素状况下，对性暗示的前瞻性注意偏见有所增加。在这些妇女中，睾丸激素和伐地那非的组合引起生殖器反应和性功能主观指标的改善。在最初对性暗示高度关注的人群中，在睾丸激素的情况下，对性暗示的前瞻性注意偏见有所降低。在这些妇女中，睾丸激素和伐地那非的组合对她们的性功能指标没有影响。结论：在性欲低下，性暗示关注度低的女性中，睾丸激素和伐地那非的组合可能是一种有希望的新疗法。

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