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Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4).

机译:在4点量表(SCORE-4)上评分与勃起功能障碍相关的结局。

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INTRODUCTION: The Erection Hardness Score (EHS), a validated single-item patient-reported outcome (PRO), may provide a simple method to capture erectile dysfunction (ED) symptoms and to monitor treatment outcome. AIM: To map the relationship between the EHS, which was used as the anchor, and other validated PROs: International Index of Erectile Function (IIEF), Quality of Erection Questionnaire (QEQ), Sexual Experience Questionnaire (SEX-Q), and Self-Esteem and Relationship questionnaire (SEAR). Methods. Data were from a trial of flexible-dose sildenafil (50 or 100 mg) in 209 men with ED. MAIN OUTCOME MEASURES: A mixed-effects repeated-measures model with EHS as a categorical explanatory variable and each of the other PROs, as a separate dependent variable, was applied to analyze the longitudinal data from randomization to the end of the 10-week, double-blind, placebo-controlled phase and the 6-week open-label phase. EHS data, which were generated at each sexual encounter (event), were averaged per patient over the same recall period that preceded administration of the other PRO questionnaires. RESULTS: Scores on all domains of the IIEF and SEX-Q, as well as the SEAR total score and SEAR Sexual Relationship domain, discriminated on all EHS categories. The QEQ total score discriminated on all EHS categories except EHS 1 and EHS 2. Although the model did not impose any functional relationship between PRO score and EHS, an approximately linear relationship existed between the EHS and all other PROs, which was especially pronounced for those PROs that were more directly related to erectile quality or function. CONCLUSIONS: The relationship between discrete EHS categories and PRO scores demonstrates the close correspondence of erectile hardness with erectile function (IIEF), erection quality (QEQ), overall sexual experience (SEX-Q), and ED-related psychosocial factors (SEAR) in men with ED.
机译:简介:勃起硬度评分(EHS)是经过验证的单项患者报告的结局(PRO),可提供一种捕获勃起功能障碍(ED)症状并监测治疗结果的简单方法。目的:绘制用作锚的EHS与其他经过验证的PRO之间的关系图:国际勃起功能指数(IIEF),勃起质量问卷(QEQ),性经验问卷(SEX-Q)和自我-Esteem和关系问卷(SEAR)。方法。数据来自209例ED男性的软剂量西地那非(50或100 mg)试验。主要观察指标:以EHS为分类解释变量,每个其他PRO作为独立因变量的混合效应重复测量模型,用于分析从随机化到10周末的纵向数据,双盲,安慰剂对照阶段和6周开放标签阶段。在每次性接触(事件)时生成的EHS数据,在给予其他PRO调查表之前的同一召回期内,平均每个患者。结果:IIEF和SEX-Q的所有领域的得分,以及SEAR总得分和SEAR性关系领域的得分,在所有EHS类别中均得到了区分。 QEQ总分在除EHS 1和EHS 2之外的所有EHS类别中均得到区分。尽管该模型未在PRO得分和EHS之间强加任何功能关系,但EHS与所有其他PRO之间存在近似线性关系,对于那些特别明显的是与勃起质量或功能更直接相关的PRO。结论:离散的EHS类别与PRO评分之间的关​​系表明,勃起硬度与勃起功能(IIEF),勃起质量(QEQ),总体性经历(SEX-Q)和ED相关的社会心理因素(SEAR)密切相关ED的男性。

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