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首页> 外文期刊>The journal of sexual medicine >Androgens and erectile function: a case for early androgen use in postprostatectomy hypogonadal men.
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Androgens and erectile function: a case for early androgen use in postprostatectomy hypogonadal men.

机译：雄激素和勃起功能：前列腺切除术后性腺功能减退男性早期使用雄激素的情况。

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INTRODUCTION: Erectile dysfunction affects up to 80% of men following a radical prostatectomy (RP) and is a common concern for these patients. Currently, hypogonadal men are not treated with testosterone after a RP for fear of stimulating dormant prostate cancer cells even though there is little evidence to support this hesitancy. There is data, however, to support the use of testosterone to aid in faster and better recovery of erections following RP. AIMS: The aim of this article is to explore the relationship between testosterone replacement therapy (TRT) and erectile preservation following RP. MAIN OUTCOME MEASURES: The results of findings in the literature on the association between testosterone and its role in preserving erectile function, particularly in men following RP. METHODS: This article reviews and evaluates the literature that demonstrates the role of testosterone in obtaining erections and preserving erectile function. Additional articles were reviewed to assess the role of testosterone in erectile preservation following RP. RESULTS: This review demonstrates that testosterone does play a role in erectile function, particularly for men who have undergone a RP. Testosterone has been shown to have an effect on nitric oxide synthase release, phosphodiesterase type 5 expression and activity, and in cavernosal nerve function, and to contribute to venoocclusive disease in the penis. All of these effects are of particular importance to men attempting to preserve erectile function following RP. CONCLUSION: While the relationship between TRT and improvement in erectile function has been well established, the role of testosterone in men following RP may be of even greater significance. However, further studies are needed to assess the true safety of TRT following RP.
机译：简介：根治性前列腺切除术（RP）后，勃起功能障碍会影响多达80％的男性，这是这些患者普遍关注的问题。目前，性腺功能减退的男性由于担心刺激休眠的前列腺癌细胞而未接受过RP的睾丸激素治疗，尽管几乎没有证据支持这种犹豫。但是，有数据支持使用睾丸激素来帮助RP后更快，更好地恢复勃起。目的：本文的目的是探讨睾丸激素替代疗法（TRT）与RP后勃起保存之间的关系。主要观察指标：文献中有关睾丸激素及其在维持勃起功能中的作用之间的关系的研究结果，尤其是在RP后的男性中。方法：本文回顾并评估了证明睾丸激素在获得勃起和维持勃起功能中的作用的文献。审查了其他文章，以评估睾丸激素在RP后勃起保存中的作用。结果：这项审查表明，睾丸激素确实在勃起功能中起作用，特别是对于经历过RP的男性。已显示睾丸激素对一氧化氮合酶的释放，5型磷酸二酯酶的表达和活性以及海绵体神经功能有影响，并有助于阴茎静脉闭塞性疾病。对于试图在RP后保持勃起功能的男性而言，所有这些作用都特别重要。结论：尽管已经充分确立了TRT与勃起功能改善之间的关系，但是RP后男性中睾丸激素的作用可能具有更大的意义。但是，还需要进一步研究来评估RP后TRT的真正安全性。

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