• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >The dose-dependent effect of chronic administration of haloperidol, risperidone, and quetiapine on sexual behavior in the male rat.
【24h】

The dose-dependent effect of chronic administration of haloperidol, risperidone, and quetiapine on sexual behavior in the male rat.

机译：长期服用氟哌啶醇，利培酮和喹硫平对雄性大鼠性行为的剂量依赖性作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Antipsychotic drug-induced sexual dysfunction is a common and problematic side effect, which may diminish quality of life and lead to treatment noncompliance. Up to date, there is still a scarcity of basic research regarding the chronic effects of most antipsychotic agents on sexual behavior. AIM: The present study investigated the effect of a range of doses of three antipsychotic drugs (haloperidol, risperidone, and quetiapine) on male rat sexual competence following chronic administration. METHODS: Twelve groups of Sprague-Dawley rats (n = 7 each) received by gavage haloperidol (0.25, 0.5, or 1 mg/kg), risperidone (0.125, 0.25, or 0.5 mg/kg), quetiapine (10, 20, and 40 mg/kg) or vehicle (distilled water) in the corresponding control groups, respectively, once daily for 21 days. Sexual function was evaluated by the copulatory behavior test 10 hours after the last dose. MAIN OUTCOME MEASURE: The male rat behavioral parameters of copulatory test. RESULTS: Sexual function was widely and significantly suppressed by high dose haloperidol (1 mg/kg) after 21 days administration compared with the control group, which included both frequency and latency of intromission and ejaculation. Only ejaculation latency was significantly impaired after administration with 0.5 mg/kg haloperidol. Compared with the control group, high dose risperidone (0.5 mg/kg) significantly decreased the frequency of mounting. There were no significant changes in sexual behavior with the lower doses of either haloperidol or risperidone. Sexual behavior was not influenced by any dose of quetiapine. CONCLUSIONS: Haloperidol and risperidone, but not quetiapine, could impair sexual competence in a dose-related manner in male rats.
机译：简介：抗精神病药诱发的性功能障碍是常见且有问题的副作用，可能会降低生活质量并导致治疗不依从。迄今为止，关于大多数抗精神病药对性行为的慢性影响的基础研究仍然很匮乏。目的：本研究调查了三种剂量的三种抗精神病药（氟哌啶醇，利培酮和喹硫平）对慢性给药后雄性大鼠性能力的影响。方法：十二只Sprague-Dawley大鼠（每组7只）分别接受氟哌啶醇（0.25、0.5或1 mg / kg），利培酮（0.125、0.25或0.5 mg / kg），喹硫平（10、20，并在相应的对照组中分别每天一次（40 mg / kg和40 mg / kg）或赋形剂（蒸馏水），每天一次，持续21天。在最后一次给药后10小时通过交配行为测试评估性功能。主要观察指标：交配测验的雄性大鼠行为参数。结果：与对照组相比，高剂量氟哌啶醇（1 mg / kg）给药后21天，性功能得到了广泛而显着的抑制，其中包括发作和射精的频率和潜伏期。用0.5 mg / kg氟哌啶醇给药后，仅射精潜伏期显着受损。与对照组相比，大剂量利培酮（0.5 mg / kg）显着降低了贴壁频率。氟哌啶醇或利培酮的剂量较低时，性行为无明显变化。性行为不受任何喹硫平剂量的影响。结论：氟哌啶醇和利培酮，但非喹硫平，可能以剂量相关的方式损害雄性大鼠的性能力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号