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首页> 外文期刊>The journal of sexual medicine >Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2).
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Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2).

机译：在两名荷兰白人男性中，采用自体精液进行低敏治疗：对高潮后疾病综合症的有益作用（POIS;第2部分）。

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INTRODUCTION: Postorgasmic illness syndrome (POIS) is a post-ejaculatory complex of local and/or systemic symptoms that nearly always occurs within seconds, minutes, or hours post-masturbation, coitus, or spontaneous ejaculation. Recent data suggest an autoimmunogenic/allergic underlying mechanism. AIM: To treat males with POIS by hyposensitization with their own semen (autologous semen). METHODS: Two males suffering from POIS, of which one male with coincidental lifelong premature ejaculation (PE) were investigated. Based on their local and systemic symptoms including a positive dermatologic reaction after skin-prick testing with autologous semen, auto-allergy to semen was likely an underlying mechanism. A hyposensitization program was initiated, including multiple subcutaneous (SC) injections with autologous semen, initially at 2 weeks intervals in the first year and gradually at 4 weeks intervals in the second and third year. From initial semen dilutions of 1 on 40,000 and 1 on 20,000, the titers were gradually increased to 1 on 20 and 1 to 280, respectively. MAIN OUTCOME MEASURES: Evaluation with a dedicated questionnaire about severity of POIS symptoms and specialized interviews on self-perceived intravaginal ejaculation latency times (IELT) before and during the desensitization program. RESULTS: POIS was confirmed in both subjects, PE was confirmed in one male, and skin-prick tests with autologous semen in both subjects were positive. During the program, gradual reduction of complaints resulted in 60% and 90% amelioration of POIS complaints at 31 and 15 months, respectively, which coincided in one male with a delay of the IELT from 20 seconds at baseline to 10 minutes after 3 years of treatment. The cause of this association with IELT is unknown and remains to be elucidated. CONCLUSIONS: Two males with POIS were successfully treated by hyposensitization with autologous semen, which supports an immunogenic/allergic etiology and underscores the clinical implication for immunological sexual medicine.
机译：简介：高潮后综合症（POIS）是射精后局部和/或全身症状的复合体，几乎总是在手淫，性交或自发射精后的几秒钟，几分钟或几小时内发生。最近的数据表明自身免疫原性/过敏性潜在机制。目的：通过对自己的精液（自体精液）过敏来治疗男性POIS。方法：调查了两名患有POIS的男性，其中一名男性患有终生性早泄（PE）。基于他们的局部和全身症状，包括用自体精液对皮肤进行点刺试验后出现阳性皮肤病反应，对精液的自动过敏可能是其潜在机制。开始进行低敏化程序，包括多次注射自体精液的皮下（SC），第一年开始时间隔2周，第二年和第三年开始间隔4周。从最初的40,000精液稀释度和20,000的1精液稀释度，滴度分别逐渐增加至20的1稀释度和1至280的稀释度。主要观察指标：在脱敏计划之前和期间，用专门的问卷调查POIS症状的严重程度，并对自我感知的阴道内射精潜伏时间（IELT）进行专门访谈。结果：两个受试者均证实了POIS，一名男性中证实了PE，并且两个受试者中自体精液的皮肤点刺试验均为阳性。在该计划中，投诉的逐渐减少导致POIS投诉在31和15个月时分别得到60％和90％的缓解，其中一名男性的IELT延迟时间从基线的20秒降至3年后的10分钟。治疗。与IELT相关的原因尚不清楚，并且有待阐明。结论：通过自体精液低敏化成功治疗了两名男性POIS，这支持免疫原性/过敏性病因，并强调了免疫性医学的临床意义。

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