Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study).

Buvat J; Montorsi F; Maggi M; Porst H; Kaipia A; Colson MH; Cuzin B; Moncada I; Martin Morales A; Yassin A; Meuleman E; Eardley I; Dean JD; Shabsigh R

首页> 外文期刊>The journal of sexual medicine >Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study).

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Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study).

机译：对PDE5抑制剂他达拉非无反应的性腺机能减退男性受益于用1％的水醇睾丸激素凝胶使睾丸激素水平正常化来治疗勃起功能障碍（TADTEST研究）。

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INTRODUCTION: Addition of testosterone (T) may improve the action of phosphodiesterase type 5 inhibitors (PDE5-Is) in patients with erectile dysfunction not responding to PDE5-Is with low or low-normal T levels. AIMS: To confirm this add-on effect of T in men optimally treated with PDE5-Is and to specify the baseline T levels at which such an effect becomes significant. METHODS: A multicenter, multinational, double-blind, placebo-controlled study of 173 men, 45-80 years, nonresponders to treatment with different PDE5-Is, with baseline total T levels

机译：简介：对于那些对T水平低或正常的PDE5-I无反应的勃起功能障碍患者，添加睾丸激素（T）可能会改善磷酸二酯酶5型抑制剂（PDE5-Is）的作用。目的：为了证实T在男性中接受PDE5-Is最佳治疗的这种附加作用，并确定基线T水平，这种水平在这种情况下变得明显。方法：一项多中心，多国，双盲，安慰剂对照研究，研究对象为173名45-80岁男性，对不同PDE5-I的治疗无反应，基线总T水平

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《The journal of sexual medicine》 |2011年第1期|共10页
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Buvat J; Montorsi F; Maggi M; Porst H; Kaipia A; Colson MH; Cuzin B; Moncada I; Martin Morales A; Yassin A; Meuleman E; Eardley I; Dean JD; Shabsigh R;
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1. Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study). [J] . Buvat J, Montorsi F, Maggi M, The journal of sexual medicine . 2011,第1期

机译：对PDE5抑制剂他达拉非无反应的性腺机能减退男性受益于用1％的水醇睾丸激素凝胶使睾丸激素水平正常化来治疗勃起功能障碍（TADTEST研究）。
2. Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. [J] . Shabsigh R, Kaufman JM, Steidle C, The Journal of Urology . 2008,第5Suppla期

机译：睾丸激素凝胶作为西地那非辅助治疗未单独对西地那非有反应的勃起功能障碍的性腺功能减退男性的随机研究。
3. Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. [J] . Shabsigh R, Kaufman JM, Steidle C The Journal of Urology . 2008,第5Suppla期

机译：睾丸激素凝胶作为西地那非辅助治疗未单独对西地那非有反应的勃起功能障碍的性腺功能减退男性的随机研究。
4. Synergetic effect of testosterone and phophodiesterase-5 inhibitors in hypogonadal men with erectile dysfunction: A systematic review [O] . Naif Alhathal, Ahmed M. Elshal, Serge Carrier 2012

机译：睾丸激素和磷酸二酯酶-5抑制剂对性腺功能减退男性勃起功能障碍的协同作用：系统评价
5. Does sildenafil combined with testosterone gel improve erectile dysfunction in hypogonadal men in whom testosterone supplement therapy alone failed [O] . Alexander Greenstein, Nicola J. Mabjeesh, Mario Sofer, 2015

机译：西地那非联合睾酮凝胶治疗性腺功能减退男性的勃起功能障碍，单独使用睾酮补充治疗失败

Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study).

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