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首页> 外文期刊>The journal of sexual medicine >Effect of niacin on erectile function in men suffering erectile dysfunction and dyslipidemia.
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Effect of niacin on erectile function in men suffering erectile dysfunction and dyslipidemia.

机译：烟酸对患有勃起功能障碍和血脂异常的男性勃起功能的影响。

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INTRODUCTION: Dyslipidemia is closely related to erectile dysfunction (ED). Evidence has shown that the lipid-lowering agent, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statins), can improve erectile function. However, information about the potential role of another class of lipid-lowering agent, niacin, is unknown. AIM: To assess the effect of niacin alone on erectile function in patients suffering from both ED and dyslipidemia. METHODS: A single center prospective randomized placebo-controlled parallel-group trial was conducted. One hundred sixty male patients with ED and dyslipidemia were randomized in a one-to-one ratio to receive up to 1,500 mg oral niacin daily or placebo for 12 weeks. MAIN OUTCOME MEASURES: The primary outcome measure was the improvement in erectile function as assessed by question 3 and question 4 of the International Index of Erectile Function (IIEF Q3 and Q4). Secondary outcome measurements included the total IIEF score, IIEF-erectile function domain, and Sexual Health Inventory for Men (SHIM) score. RESULTS: From the overall analysis, the niacin group showed a significant increase in both IIEF-Q3 scores (0.53 +/- 1.18, P < 0.001) and IIEF-Q4 scores (0.35 +/- 1.17, P = 0.013) compared with baseline values. The placebo group also showed a significant increase in IIEF-Q3 scores (0.30 +/- 1.16, P = 0.040) but not IIEF-Q4 scores (0.24 +/- 1.13, P = 0.084). However, when patients were stratified according to the baseline severity of ED, the patients with moderate and severe ED who received niacin showed a significant improvement in IIEF-Q3 scores (0.56 +/- 0.96 [P = 0.037] and 1.03 +/- 1.20 [P < 0.001], respectively) and IIEF-Q4 scores (0.56 +/- 1.03 [P = 0.048] and 0.84 +/- 1.05 [P < 0.001], respectively] compared with baseline values, but not for the placebo group. The improvement in IIEF-EF domain score for severe and moderate ED patients in the niacin group were 5.28 +/- 5.94 (P < 0.001) and 3.31 +/- 4.54 (P = 0.014) and in the placebo group were 2.65 +/- 5.63 (P < 0.041) and 2.74 +/- 5.59 (P = 0.027), respectively. There was no significant improvement in erectile function for patients with mild and mild-to-moderate ED for both groups. For patients not receiving statins treatment, there was a significant improvement in IIEF-Q3 scores (0.47 +/- 1.16 [P = 0.004]) for the niacin group, but not for the placebo group. CONCLUSIONS: Niacin alone can improve the erectile function in patients suffering from moderate to severe ED and dyslipidemia.
机译：引言：血脂异常与勃起功能障碍（ED）密切相关。有证据表明，降脂剂3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）可以改善勃起功能。但是，有关另一类降脂剂烟酸的潜在作用的信息尚不清楚。目的：评估单独烟酸对患有ED和血脂异常的患者勃起功能的影响。方法：进行了一项单中心前瞻性随机安慰剂对照平行组试验。一百六十例患有ED和血脂异常的男性患者以一对一的比例被随机分配，每天接受高达1500 mg烟酸或安慰剂口服12周。主要观察指标：主要结局指标是勃起功能的改善，这是由国际勃起功能指数（IIEF Q3和Q4）的问题3和问题4评估得出的。次要结局指标包括IIEF总得分，IIEF勃起功能域和男性性健康清单（SHIM）得分。结果：从总体分析来看，烟酸组的IIEF-Q3得分（0.53 +/- 1.18，P <0.001）和IIEF-Q4得分（0.35 +/- 1.17，P = 0.013）均显着增加价值观。安慰剂组的IIEF-Q3评分也显着增加（0.30 +/- 1.16，P = 0.040），但IIEF-Q4评分没有显着增加（0.24 +/- 1.13，P = 0.084）。但是，当根据ED的基线严重程度对患者进行分层时，接受烟酸的中度和重度ED患者的IIEF-Q3评分显着改善（0.56 +/- 0.96 [P = 0.037]和1.03 +/- 1.20与基线值相比，分别为[P <0.001]和IIEF-Q4得分（分别为0.56 +/- 1.03 [P = 0.048]和0.84 +/- 1.05 [P <0.001]），但对于安慰剂组则没有。烟酸组重度和中度ED患者的IIEF-EF域评分改善为5.28 +/- 5.94（P <0.001）和3.31 +/- 4.54（P = 0.014），而安慰剂组为2.65 +/- ED分别为5.63（P <0.041）和2.74 +/- 5.59（P = 0.027），两组中轻度和中度ED患者的勃起功能均无显着改善。烟酸组IIEF-Q3评分有显着改善（0.47 +/- 1.16 [P = 0.004]），而安慰剂组则没有。孤独症可以改善中度至重度ED和血脂异常患者的勃起功能。

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