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首页> 外文期刊>The journal of sexual medicine >Association Between Viral Hepatitis and Erectile Dysfunction: A Population-Based Case-Control Analysis
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Association Between Viral Hepatitis and Erectile Dysfunction: A Population-Based Case-Control Analysis

机译：病毒性肝炎和勃起功能障碍之间的关联：基于人群的病例对照分析

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Introduction. Chronic liver diseases are often accompanied by hypogonadism, testicular atrophy, and a reduction in libido, all of which are factors that may contribute to the development of erectile dysfunction (ED). However, large-scaled studies investigating the association between ED and viral hepatitis are still sparse. Aim. This study aimed to estimate the association between ED and a prior diagnosis of viral hepatitis using a population-based dataset with a case-control design in Taiwan. Methods. We identified 6,429 patients with ED as cases and randomly selected 32,145 subjects as controls. We used conditional logistic regression to compute the odds ratio (OR) for having previously received a diagnosis of viral hepatitis between cases and controls. Main Outcome Measure. The prevalence and odds of having been previously diagnosed with hepatitis B, hepatitis C, a coinfection with hepatitis B and C, and viral hepatitis of other etiology were calculated between cases and controls. Results. Of the 38,574 sampled subjects, 3,930 (10.2%) had viral hepatitis before the index date; viral hepatitis was found in 900 (14.0%) cases and in 3,030 (9.4%) controls. After adjusting for monthly income, geographic location, hypertension, diabetes, hyperlipidemia, hepatic steatosis, coronary heart disease, obesity, and alcohol abuse/alcohol dependence syndrome, cases were found to be more likely to have prior viral hepatitis than controls (OR=1.51, 95% confidence interval [CI]=1.39-1.64, P<0.001). A much higher proportion of coinfection with viral hepatitis B and C was additionally found among cases (OR=1.84, 95% CI=1.72-1.97) than controls. Conclusions. We conclude that ED was associated with prior viral hepatitis, especially with a coinfection of hepatitis B and C, after adjusting for potential confounders.
机译：介绍。慢性肝病通常伴有性腺功能低下，睾丸萎缩和性欲降低，所有这些因素都可能导致勃起功能障碍（ED）的发展。但是，有关ED与病毒性肝炎之间关系的大规模研究仍很少。目标。这项研究旨在使用台湾的病例对照设计的人群数据来估计ED与病毒性肝炎的先前诊断之间的关联。方法。我们确定了6429例ED患者为病例，并随机选择32145例受试者作为对照。我们使用条件逻辑回归来计算先前在病例和对照之间接受过病毒性肝炎诊断的比值比（OR）。主要结果指标。在病例和对照组之间计算了先前被诊断出患有乙型肝炎，丙型肝炎，乙型和丙型肝炎合并感染以及其他病因的病毒性肝炎的患病率和患病率。结果。在38574名样本中，有3930名（10.2％）在分娩日期之前患有病毒性肝炎;在900（14.0％）例和3030（9.4％）例中发现了病毒性肝炎。在调整了月收入，地理位置，高血压，糖尿病，高脂血症，肝脂肪变性，冠心病，肥胖症和酗酒/酗酒综合症后，发现病例比对照组更容易患上病毒性肝炎（OR = 1.51 ，95％置信区间[CI] = 1.39-1.64，P <0.001）。在病例中（OR = 1.84，95％CI = 1.72-1.97），与乙型肝炎和乙型肝炎合并感染的比例更高。结论。我们得出的结论是，在调整了潜在的混杂因素之后，ED与先前的病毒性肝炎有关，尤其是与乙型和丙型肝炎合并感染。

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