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首页> 外文期刊>The journal of sexual medicine >Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?
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Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?

机译：非那雄胺的持久性副作用：它们可以永久存在吗？

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Introduction. Finasteride has been associated with sexual side effects that may persist despite discontinuation of the medication. In a clinical series, 20% of subjects with male pattern hair loss reported persistent sexual dysfunction for ≥6 years, suggesting the possibility that the dysfunction may be permanent. These subjects also reported a wide range of symptoms including changes in cognition, ejaculate quality, and genital sensation. Other medications have been associated with irreversible neurological effects, such as phenothiazines with tardive dyskinesias. Aim. To prospectively study whether the persistent sexual side effects associated with finasteride resolve or endure over time. Methods. Subjects (N=54) with persistent sexual side effects associated with finasteride were reassessed after 9-16 months (mean 14 months). All subjects were otherwise healthy young men without any baseline sexual dysfunction, medical conditions, psychiatric conditions, or use of oral prescription medications prior to taking finasteride for male pattern hair loss. Main Outcome Measure. Scores from the Arizona Sexual Experience Scale (ASEX). Results. The participation rate was 81%. At reassessment persistent sexual side effects continued to be present in 96% of subjects. According to the ASEX scores, 89% of subjects met the definition of sexual dysfunction. Neither the length of finasteride use nor the duration of the sexual side effects correlated to changes in scores of sexual dysfunction. Conclusion. In most men who developed persistent sexual side effects (≥3 months) despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years. Although several rat studies have shown detrimental changes to erectile function caused by 5 alpha reductase inhibitors, the persistent nature of these changes is an area of active research. Prescribers of finasteride and men contemplating its use should be made aware of the potential adverse medication effects.
机译：介绍。非那雄胺与性副作用有关，尽管该药停用可能仍会持续。在一个临床系列中，有20％的男性脱发受试者报告了≥6年的持续性功能障碍，这表明该功能障碍可能是永久性的。这些受试者还报告了广泛的症状，包括认知，射精质量和生殖器感觉的变化。其他药物也曾与不可逆的神经功能有关，例如吩噻嗪类药物具有迟发性运动障碍。目标。前瞻性研究与非那雄胺有关的持续性副作用是否会随着时间的流逝而消失或持久。方法。 9-16个月（平均14个月）后，对具有持续性与非那雄胺相关的性副作用的受试者（N = 54）进行了重新评估。所有受试者均为健康的年轻人，没有任何基线性功能障碍，医疗状况，精神病状况，或在服用非那雄胺治疗男性型脱发之前使用口服处方药。主要结果指标。来自亚利桑那州性经验量表（ASEX）的分数。结果。参与率为81％。在重新评估时，持续的性副作用持续存在于96％的受试者中。根据ASEX评分，有89％的受试者符合性功能障碍的定义。非那雄胺的使用时间或性副作用的持续时间均与性功能障碍评分的变化无关。结论。在大多数停用非那雄胺的情况下仍持续出现性副作用（≥3个月）的男性中，性功能障碍持续了数月或数年。尽管一些大鼠研究显示了由5α还原酶抑制剂引起的勃起功能的有害变化，但是这些变化的持久性是活跃研究的领域。非那雄胺的处方者和打算使用非那雄胺的男性应告知他们潜在的药物不良反应。

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