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首页> 外文期刊>The journal of sexual medicine >The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men
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The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

机译：与男性发生性关系的男性使用药物，吸毒和吸烟对勃起功能障碍的累积影响

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Introduction. Erectile dysfunction (ED) is highly prevalent among human immunodeficiency virus-seropositive (HIV+) men who have sex with men (MSM). There is a need for additional research to determine the correlates of HIV+ and HIV-seronegative (HIV-) MSM, especially regarding nonantiretroviral medication use. Aims. This study examined the prevalence of ED and the sociodemographic, medical conditions, medication use, and substance use correlates of ED among HIV+ and HIV- MSM. Methods. A modified version of the International Index of Erectile Function (IIEF) for MSM was self-administered by participants enrolled in the Multicenter AIDS Cohort Study, an ongoing prospective study of the natural and treated histories of HIV infection among MSM in the United States. The study sample included 1,340 participants, including 612 HIV+ and 728 HIV- men. Poisson regression with robust error variance was used to estimate prevalence ratios of ED in multivariable models in combined (HIV+/-) and separate analyses. Main Outcome Measure. ED was determined by the summed scores of a modified version of the IIEF validated among MSM. Results. Twenty-one percent of HIV+ MSM and 16% of HIV- MSM reported ED. Being >55years of age, black race, cumulative pack years of smoking, cumulative antihypertensive use, and cumulative antidepressant use had significant positive associations with the prevalence of ED in the total sample. Among HIV+ men, duration of antihypertensive use and antidepressant use were significantly associated with increasing prevalence of ED. Among HIV- men, being >55years of age, black race, and cigarette smoking duration were associated with increased prevalence of ED. Conclusion. Predictors of ED may differ by HIV status. Although smoking cessation and effective medication management may be important as possible treatment strategies for ED among all MSM, there may be a burden on sexual functioning produced by non-HIV medications for HIV+ men. Hart TA, Moskowitz D, Cox C, Li X, Ostrow DG, Stall RD, Gorbach PM, and Plankey M. The cumulative effects of medication use, drug use, and smoking on erectile dysfunction among men who have sex with men.
机译：介绍。在与男性发生性关系的人类免疫缺陷病毒血清阳性（HIV +）男性中，勃起功能障碍（ED）非常普遍。需要进行更多的研究来确定HIV +和HIV血清阴性（HIV-）MSM的相关性，尤其是在使用非抗逆转录病毒药物方面。目的这项研究检查了ED的患​​病率以及HIV +和HIV-MSM中ED的社会人口统计学，医学状况，药物使用和药物使用相关性。方法。参与多中心艾滋病队列研究的参与者自行管理了MSM国际勃起功能指数（IIEF）的修改版本，该研究是一项针对美国MSM中自然和治疗过的HIV感染史的前瞻性研究。该研究样本包括1,340名参与者，其中包括612名HIV +和728名HIV-男性。结合稳健误差方差的Poisson回归用于在组合（HIV +/-）和单独分析中估算多变量模型中ED的患病率。主要结果指标。 ED由MSM中经过验证的IIEF修改版的总分确定。结果。 21％的HIV + MSM和16％的HIV- MSM报告患有ED。年龄> 55岁，黑人种族，累积吸烟年数，累积抗高血压药的使用和累积抗抑郁药的使用与总样本中ED的患病率显着正相关。在HIV +男性中，抗高血压药和抗抑郁药的使用时间与ED的患病率显着相关。在超过55岁的艾滋病病毒感染者中，黑人种族和吸烟时间与ED患病率增加有关。结论。 ED的预测因素可能因HIV状况而异。尽管在所有MSM中，戒烟和有效的药物管理作为ED的可能治疗策略可能很重要，但对于HIV +男性而言，非HIV药物可能会对性功能造成负担。 Hart TA，Moskowitz D，Cox C，Li X，Ostrow DG，Stall RD，Gorbach PM和PlankeyM。药物使用，药物使用和吸烟对男性勃起功能障碍的累积影响。

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