• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: A pilot study
【24h】

Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: A pilot study

机译：性腺功能减退男性运动员睾丸激素替代治疗期间监测血清雄激素的担忧：一项先导研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction. A well-tailored testosterone replacement treatment (TRT) in male hypogonadal athletes plays a pivotal role to restore physiological performances, to reduce health risks, and to guarantee the ethic of competition. Few studies evaluated individual androgens profiles during TRT in trained individuals. Aim. The aim of this article was to verify the efficacy in restoring eugonadal serum and urinary androgens profiles after testosterone enanthate (TE) and gel (TG) administration. Methods. Ten male Caucasian-trained volunteers affected by severe hypotestosteronemia (<8nmol/L) were included. Serum androgens and urinary testosterone metabolites were evaluated, in the same subjects, before and weekly for 5weeks after both a single intramuscular TE injection (250mg) and during a daily administration of TG (50mg/die of testosterone), respectively. Main Outcome Measures. The main outcome measures of this article were serum total testosterone (TT), dihydrotestosterone (DHT), calculated free and bioavailable testosterone (cFT, cBioT), 17-β-estradiol, and urinary glucuronide testosterone metabolites. Results. Supraphysiological TT concentrations were observed in 50% of our volunteers until 7days after TE and in the 4% of total samples after TG. Serum DHT was high both after TE (all volunteers on day 7 and 50% on day 14) and during TG (32% of total samples). A relatively low number of samples showed normal cFT and cBioT both after TE and TG (20-44%, respectively). Urinary metabolites were related to the type of treatment and to serum androgens profile and resulted in the normal ranges from 15% to 60% of total samples. Conclusion. Besides well-known variations of mean serum TT, we showed a high percentage of serum and urinary samples with abnormal androgens, being TG safer than TE. We conclude that monitoring TRT with TT only may be inaccurate because of abnormal fluctuations of other circulating androgens. Further studies to identify the appropriate markers of eugonadism during TRT are highly warranted both in athletes and in non-athletes.
机译：介绍。男性性腺功能减退运动员中度身定制的睾丸激素替代治疗（TRT）在恢复生理机能，降低健康风险和保证比赛道德方面起着关键作用。很少有研究评估训练有素的个体在TRT期间的个体雄激素谱。目标。本文的目的是验证施用庚酸酯（TE）和凝胶（TG）后恢复性腺血清和尿雄激素谱的功效。方法。包括十名受严重低睾酮血症（<8nmol / L）影响的男性，经白种人培训的志愿者。在同一受试者中，在单次肌注TE（250mg）和每日TG（每天50mg /只睾丸）给药后5周之前和每周，在同一受试者中评估血清雄激素和尿中睾丸激素代谢物。主要观察指标。本文的主要结局指标是血清总睾丸激素（TT），二氢睾丸激素（DHT），游离和可生物利用的睾丸激素（cFT，cBioT），17-β-雌二醇和尿葡萄糖醛酸睾丸激素代谢产物。结果。在我们的志愿者中，有50％的人在TE术后7天之前观察到超生理性TT浓度，而在TG后的总样本中有4％观察到超生理性TT浓度。 TE后（所有志愿者在第7天，所有志愿者在第14天）和TG期间（总样本的32％），血清DHT均较高。在TE和TG后，相对少量的样本显示cFT和cBioT正常（分别为20-44％）。尿液代谢物与治疗类型和血清雄激素水平有关，其正常范围为总样本的15％至60％。结论。除了众所周知的平均血清TT变化外，我们还显示出高百分比的血清和尿液样本中雄激素异常，TG比TE更安全。我们得出结论，由于其他循环雄激素的异常波动，仅用TT监测TRT可能是不准确的。无论是运动员还是非运动员，都需要开展进一步的研究来确定TRT期间适当的性腺功能标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号