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首页> 外文期刊>The journal of sexual medicine >Association Between Multiple Sclerosis and Erectile Dysfunction: A Nationwide Case-Control Study
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Association Between Multiple Sclerosis and Erectile Dysfunction: A Nationwide Case-Control Study

机译：多发性硬化与勃起功能障碍之间的关联：全国病例对照研究

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Background. Multiple sclerosis (MS) commonly affects young adults who may be sexually active, with sexual dysfunction being a significant, but often underestimated, symptom of MS. However, no large-scaled study has investigated the association between erectile dysfunction (ED) and MS in an Asian population to date. Objective. The objective of this study is to estimate the association between ED and a prior diagnosis of MS using a population-based dataset with a case-control design in Taiwan. Methods. The data were sourced from National Health Insurance Research Database. We identified 38,139 patients with ED as cases and randomly selected 262,848 subjects as controls. We then used conditional logistic regression to compute the odds ratio for having previously received a diagnosis of MS between cases and controls. Results. The prevalence of prior MS was 0.037% and 0.015% for cases and controls, respectively (P<0.001). Conditional logistic regression analysis revealed that cases were 2.23 times (95% confidence interval=1.15-4.32) more likely to have been previously diagnosed with MS than controls after adjusting for monthly income, geographic location, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, and alcohol abuse/alcohol dependence syndromes. Conclusions. This study revealed an association between ED and prior MS even after adjusting for potential confounders.
机译：背景。多发性硬化症（MS）通常会影响可能活跃于性活动的年轻人，而性功能障碍是MS的重要症状，但常常被低估。但是，迄今为止，尚无大规模研究调查亚洲人群中勃起功能障碍（ED）与MS之间的关系。目的。这项研究的目的是使用台湾的病例对照设计，基于人群的数据集估计ED与MS的先前诊断之间的关联。方法。数据来自国家健康保险研究数据库。我们确定38139例ED患者为病例，并随机选择262848例受试者作为对照。然后，我们使用条件逻辑回归来计算先前已在病例和对照之间接受过MS诊断的比值比。结果。病例和对照的先前MS患病率分别为0.037％和0.015％（P <0.001）。条件Logistic回归分析显示，在调整了月收入，地理位置，高血压，糖尿病，冠心病，高脂血症，肥胖和酗酒/酒精依赖综合症。结论。这项研究表明，即使在调整了潜在的混杂因素之后，ED与先前的MS之间也存在关联。

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