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首页> 外文期刊>The journal of sexual medicine >Erectile Dysfunction Is Not a Mirror of Endothelial Dysfunction in HIV-Infected Patients
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Erectile Dysfunction Is Not a Mirror of Endothelial Dysfunction in HIV-Infected Patients

机译：勃起功能障碍并非感染HIV的患者内皮功能障碍的一面镜子

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Introduction. The penis has been compared to a barometer of endothelial health, erectile dysfunction (ED) being an early sign of endothelial dysfunction. Aim. The aim of the study was to investigate the extent of the association between ED and endothelial dysfunction in patients with human immunodeficiency virus (HIV) infection on antiretroviral therapy. Methods. In this observational cross-sectional study, we evaluated the prevalence and factors associated with ED in a cohort of 133 HIV-infected men. Main Outcome Measures. The International Index of Erectile Function, ultrasound assessment of brachial artery flow mediated dilatation (FMD), and multi-slice computed tomography for coronary artery calcifications (CAC) as surrogates of endothelial dysfunction, the Adult Treatment Panel III criteria to diagnose metabolic syndrome (MS), plasma total testosterone (hypogonadism), and a visual analogue scale (VAS) of aesthetic satisfaction of the face and of the body (psychological distress associated with lipodystrophy). Results. Thirty-nine (29.32%) patients had mild ED, 14 (10.52%) patients had moderate ED, and 26 (19.55%) patients had severe ED. Prevalence of ED ranged from 45% to 65%, respectively, in patients less than 40 and more than 60 years old. MS was present in 20 (25%) patients with ED and 13 (24%) patients without ED (P value=0.87). Prevalence of ED neither appeared to be associated with MS as a single clinical pathological entity nor with the numbers of its diagnostic components. FMD<7% was present in 25 (32%) patients with ED and 18 (33%) patients without ED (P value=0.83), and CAC>100 was present in 8 (10%) patients with ED and 5 (9%) patients without ED (P value=0.87). A stepwise multivariable logistic regression analysis was used to find predictors of ED. Independent predictors were VAS face (odds ratio [OR]=0.85, 95% confidence interval [CI] 0.73-0.99, P=0.049) and age per 10 years of increase (OR=1.73, 95% CI 1.02-2.94, P=0.04). Conclusions. Age constituted the most important risk factor for ED, which was related to aesthetic dissatisfaction of the face leading to negative body image perception.
机译：介绍。已将阴茎与内皮健康晴雨表进行比较，勃起功能障碍（ED）是内皮功能障碍的早期征兆。目标。该研究的目的是研究抗逆转录病毒疗法对人免疫缺陷病毒（HIV）感染患者的ED与内皮功能障碍之间的关联程度。方法。在这项观察性横断面研究中，我们评估了133名受HIV感染的男性队列中ED的患病率和相关因素。主要观察指标。国际勃起功能指数，超声评估肱动脉血流介导的扩张（FMD）和多层计算机断层扫描作为冠状动脉钙化（CAC）的替代指标，作为内皮功能障碍的替代物，是诊断代谢综合征（MS）的成人治疗小组III标准），血浆总睾丸激素（性腺功能减退）和对面部和身体的美学满意度（与脂肪营养不良有关的心理困扰）的视觉模拟量表（VAS）。结果。三十九名（29.32％）患者患有轻度ED，十四名（10.52％）患者患有中度ED，而26名（19.55％）患者患有严重ED。年龄在40岁以下和60岁以上的患者中ED的患病率分别为45％至65％。 20例（25％）ED患者和13例（24％）无ED患者出现MS（P值= 0.87）。 ED的患病率似乎既不与MS作为单一临床病理实体相关，也不与其诊断成分的数量相关。在25例（32％）ED患者和18例（33％）无ED患者中，FMD <7％（P值= 0.83），在8例（10％）ED患者和5（9中）患者中，CAC> 100 ％）没有ED的患者（P值= 0.87）。逐步多变量logistic回归分析用于寻找ED的预测因子。独立的预测因素是VAS的面部表情（赔率[OR] = 0.85，95％置信区间[CI] 0.73-0.99，P = 0.049）和每增加10年的年龄（OR = 1.73，95％CI 1.02-2.94，P = 0.04）。结论。年龄是ED的最重要危险因素，这与面部的美学不满意相关，从而导致负面的身体形象感知。

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