• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >Incomplete Recovery of Erectile Function in Rat after Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy
【24h】

Incomplete Recovery of Erectile Function in Rat after Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy

机译：停用双重5-α-还原酶抑制剂治疗后大鼠勃起功能不完全恢复

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim. The association of 5-alpha reductase inhibitor (5ARI) therapy and sexual dysfunction has been reported. Some patients claim persistent erectile dysfunction despite long-term discontinuation of 5ARI treatment. The aim of this study was to assess erectile function after cessation of 5ARI therapy using a rat model. Methods. Twenty-six adult male Sprague-Dawley rats were randomized into three groups: (i) control (N=10); (ii) 8-week dutasteride treatment (0.5mg/rat/day, in drinking water, N=8); and (iii) 6-week dutasteride treatment followed by a 2-week washout period (N=8). The experiments were performed after 8 weeks from the initiation of treatment in all groups. In vivo erectile activity and in vitro contractile and relaxant responses of cavernosal smooth muscle were investigated. Results. In vivo erectile activity (intracavernosal pressure [ICP]/mean arterial pressure [MAP] and total ICP) in treatment groups were significantly decreased compared with controls (ICP/MAP: P<0.001 for 2.5v, 5v, and 7.5v; total ICP: P<0.001 for 5v and P<0.01 for 7.5v). Acetylcholine-induced relaxations were diminished in treatment groups (P<0.05). Relaxant responses to electrical field stimulation (EFS) were decreased in the 8-week treatment group (P<0.05) but were similar to controls in the washout group. Sodium nitroprusside (SNP)-induced endothelium-independent relaxations were reduced in the 8-week dutasteride treatment group (P<0.01), while these responses were restored in the washout group. The contractile responses to the alpha1-adrenergic agonist phenylephrine were decreased in treatment groups compared with controls (P<0.01). Direct neurogenic contractile responses in the dutasteride groups were significantly lower than controls between 1 and 15Hz frequencies (but not at 20Hz) and washout partially restored the responses at 10 and 15Hz. Conclusion. Discontinuation of dutasteride improved the relaxant responses to EFS and SNP, while cholinergic and adrenergic responses remained depressed. Our findings suggest a time-dependent detriment of dutasteride on erectile function. The withdrawal/washout effect of 5ARIs on parameters of human sexual function warrants further investigation.
机译：目标。据报道5-α还原酶抑制剂（5ARI）治疗与性功能障碍有关。尽管长期停用5ARI治疗，一些患者仍声称持续性勃起功能障碍。这项研究的目的是使用大鼠模型评估停止5ARI治疗后的勃起功能。方法。将26只成年雄性Sprague-Dawley大鼠随机分为三组：（i）对照（N = 10）; （ii）8周度他雄胺治疗（0.5 mg /大鼠/天，在饮用水中，N = 8）; （iii）度他雄胺治疗6周，然后进行2周清除期（N = 8）。所有组从治疗开始8周后进行实验。研究了海绵体平滑肌的体内勃起活性以及体外收缩和松弛反应。结果。与对照组相比，治疗组的体内勃起活性（颅内压[ICP] /平均动脉压[MAP]和总ICP）显着降低（ICP / MAP：对于2.5v，5v和7.5v，P <0.001;总ICP ：对于5v，P <0.001，对于7.5v，P <0.01）。治疗组乙酰胆碱引起的松弛减少（P <0.05）。在8周的治疗组中，对电场刺激（EFS）的松弛反应有所降低（P <0.05），但与冲洗组的对照组相似。度他雄胺治疗组8周减少了硝普钠（SNP）诱导的内皮依赖性舒张（P <0.01），而冲洗组恢复了这些反应。与对照组相比，治疗组对α1-肾上腺素能激动剂去氧肾上腺素的收缩反应降低（P <0.01）。度他雄胺组的直接神经源性收缩反应显着低于对照组（在1和15Hz频率之间（但不是在20Hz）），冲刷可部分恢复10和15Hz的反应。结论。停用度他雄胺改善了对EFS和SNP的松弛反应，而胆碱能和肾上腺素能反应仍然低落。我们的发现表明，度他雄胺对勃起功能有时间依赖性。 5ARIs对人性功能参数的戒断/冲刷作用值得进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号