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首页> 外文期刊>The journal of sexual medicine >Sex steroid hormones in diabetes-induced sexual dysfunction: focus on the female gender.
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Sex steroid hormones in diabetes-induced sexual dysfunction: focus on the female gender.

机译：糖尿病引起的性功能障碍中的性类固醇激素：专注于女性。

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INTRODUCTION: Diabetes is associated with gender-specific changes in sex steroid hormones. However, the mechanisms responsible for these associations as well as the link to sexual dysfunction are not well understood. AIM: To discuss key clinical and laboratory findings linking diabetes, sex steroid hormones, and sexual dysfunction, with particular focus on the female gender. METHODS: A comprehensive literature review was conducted using the PubMed database. Search terms were used in appropriate combinations, including diabetes, insulin, insulin sensitivity, androgen, estrogen, sexual function, women, men, estrogen receptor, and androgen receptor. Over 400 citations were selected, based on topical relevance, and examined for study methodology and major findings. MAIN OUTCOME MEASURES: Data from peer-reviewed publications. RESULTS: Imbalances in sex steroid hormone levels are strongly associated with diabetes and this may negatively impact upon sexual function. Although numerous factors are likely to contribute to the development of diabetes and its complications, the role of sex steroid hormones must be acknowledged. CONCLUSIONS: Research related to diabetic women and sexual dysfunction is severely lacking. Identifying underlying causes for a given hormonal imbalance in diabetic patients, as well as determination of genetic and age-dependent factors, will become important in identifying the subpopulations in which hormonal replacement regimens will be most effective. Investigation into treating diabetic patients with adjunct hormonal therapies or steroid hormone receptor modulators holds much promise.
机译：简介：糖尿病与性类固醇激素的性别特异性改变有关。但是，导致这些关联的机制以及与性功能障碍的联系尚不十分清楚。目的：讨论与糖尿病，性类固醇激素和性功能障碍有关的关键临床和实验室发现，特别关注女性。方法：使用PubMed数据库进行了全面的文献综述。搜索词以适当的组合使用，包括糖尿病，胰岛素，胰岛素敏感性，雄激素，雌激素，性功能，女性，男性，雌激素受体和雄激素受体。根据主题相关性，选择了400多个引用文献，并检查了研究方法和主要发现。主要观察指标：来自同行评审出版物的数据。结果：性类固醇激素水平失衡与糖尿病密切相关，这可能对性功能产生负面影响。尽管可能有多种因素导致糖尿病及其并发症的发生，但必须承认性类固醇激素的作用。结论：严重缺乏与糖尿病妇女和性功能障碍有关的研究。查明糖尿病患者给定的荷尔蒙失调的根本原因，以及确定遗传因素和年龄依赖性因素，对于确定最有效的荷尔蒙替代治疗方案的亚人群将变得很重要。辅助激素疗法或类固醇激素受体调节剂治疗糖尿病患者的研究前景广阔。

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