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首页> 外文期刊>The journal of sexual medicine >Oral phosphodiesterase type 5 inhibitors alleviate recurrent priapism complicating thalassemia intermedia: a case report.
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Oral phosphodiesterase type 5 inhibitors alleviate recurrent priapism complicating thalassemia intermedia: a case report.

机译：口服磷酸二酯酶5型抑制剂可缓解复发性阴茎异常勃起并发中地中海贫血：一例病例。

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INTRODUCTION: Recurrent ischemic priapism still remains a serious and difficult to treat complication of certain hematological disorders. Elucidation of the underlying pathophysiologic mechanisms and application of new effective prophylactic treatments are needed. AIM: To present the efficacy of phosphodiesterase type 5 inhibitors (PDE5is) as a preventive measure against ischemic priapism recurrences complicating thalassemia intermedia. METHODS: We report on the case of a 19-year-old Caucasian man with thalassemia intermedia complicated by recurrent episodes of priapism following therapeutic splenectomy. After failure of conventional measures to control recurrences, a trial of long-term PDE5is use was initiated. MAIN OUTCOME MEASURES: PDE5is efficacy based on clinical patient history. RESULTS: Within 2 months of PDE5i preventive strategy, priapism recurrences nearly resolved. At 6 months, prophylaxis was discontinued. At 12 months, the patient reported clear improvement and satisfaction, experiencing rare episodes of priapism and a physiologic erectile function. CONCLUSIONS: PDE5 dysregulation seems to be an underline pathogenetic mechanism of thalassemia intermedia-associated priapism. It appears that PDE5is might have a role in the clinical management of such patients and their preventive efficacy warrants further testing in clinical trials.
机译：引言：复发性缺血性阴茎异常勃起仍然是一种严重且难以治疗的某些血液系统疾病的并发症。需要阐明潜在的病理生理机制并应用新的有效预防措施。目的：介绍5型磷酸二酯酶抑制剂（PDE5is）作为预防缺血性阴茎异常勃起复发（使地中海贫血中间型复杂化）的预防措施的功效。方法：我们报道了一名19岁的白人男子，患有地中海贫血并伴发脾脏切除术后复发性反复发作的一例。在常规措施未能控制复发后，开始了长期使用PDE5的试验。主要观察指标：PDE5是基于临床患者病史的疗效。结果：在PDE5i预防策略的2个月内，阴茎异常复发几乎得以解决。在6个月时，停止预防。在12个月时，患者报告明显改善和满意，经历了罕见的阴茎异常勃起和生理勃起功能。结论：PDE5失调似乎是地中海贫血与中枢性狂热症的发病机制。似乎PDE5is可能在此类患者的临床管理中起作用，其预防功效值得在临床试验中进行进一步测试。

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