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首页> 外文期刊>The journal of sexual medicine >Potential of adipose-derived stem cells for treatment of erectile dysfunction.
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Potential of adipose-derived stem cells for treatment of erectile dysfunction.

机译：脂肪干细胞治疗勃起功能障碍的潜力。

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INTRODUCTION: Adipose-derived stem cells (ADSCs) are a somatic stem cell population contained in fat tissue that possess the ability for self-renewal, differentiation into one or more phenotypes, and functional regeneration of damaged tissue, which may benefit the recovery of erectile function by using a stem cell-based therapy. AIM: To review available evidence concerning ADSCs availability, differentiation into functional cells, and the potential of these cells for the treatment of erectile dysfunction (ED). METHODS: We examined the current data (from 1964 to 2008) associated with the definition, characterization, differentiation, and application of ADSCs, as well as other kinds of stem cells for the cell-based therapies of ED. MAIN OUTCOME MEASURES: There is strong evidence supporting the concept that ADSCs may be a potential stem cell therapy source in treating ED. RESULTS: The ADSCs are paravascularly localized in the adipose tissue. Under specific induction medium conditions, these cells differentiated into neuron-like cells, smooth muscle cells, and endothelium in vitro. The insulin-like growth factor/insulin-like growth factor receptor (IGF/IGFR) pathway participates in neuronal differentiation while the fibroblast growth factor 2 (FGF2) pathway is involved in endothelium differentiation. In a preliminary in vivo experiment, the ADSCs functionally recovered the damaged erectile function. However, the underlying mechanism needs to be further examined. CONCLUSION: The ADSCs are a potential source for stem cell-based therapies, which imply the possibility of an effective clinical therapy for ED in the near future.
机译：简介：脂肪干细胞（ADSC）是脂肪组织中包含的一种体细胞干细胞，具有自我更新，分化为一种或多种表型以及受损组织功能性再生的能力，这可能有益于勃起的恢复。通过使用基于干细胞的疗法来发挥作用。目的：回顾有关ADSC可用性，分化为功能性细胞以及这些细胞治疗勃起功能障碍（ED）潜力的现有证据。方法：我们检查了从1964年到2008年的当前数据，这些数据与ADSCs的定义，表征，分化和应用以及用于基于细胞的ED治疗的其他类型干细胞有关。主要观察指标：有强有力的证据支持ADSCs可能是治疗ED的潜在干细胞治疗来源的概念。结果：ADSCs位于脂肪组织的血管旁。在特定的诱导培养基条件下，这些细胞在体外分化为神经元样细胞，平滑肌细胞和内皮细胞。胰岛素样生长因子/胰岛素样生长因子受体（IGF / IGFR）途径参与神经元分化，而成纤维细胞生长因子2（FGF2）途径参与内皮分化。在初步的体内实验中，ADSC在功能上恢复了受损的勃起功能。但是，需要进一步研究其基本机制。结论：ADSCs是基于干细胞疗法的潜在来源，这暗示了在不久的将来针对ED的有效临床疗法的可能性。

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