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首页> 外文期刊>The journal of sexual medicine >Multipotent Stromal Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction
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Multipotent Stromal Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction

机译：多能基质细胞治疗海绵状神经损伤引起的勃起功能障碍

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Introduction. Erectile dysfunction (ED) following radical prostatectomy (RP) is a result of inadvertent damage to the cavernous nerves that run close to the prostate capsula. The mechanisms behind the development of post-RP ED are increasingly recognized and include cavernosal fibrosis and cavernosal smooth muscle apoptosis, resulting from cavernous nerve degeneration due to neuropraxia. In recent years, cell-based therapies have received increasing attention regarding their potential for recovery of erectile function following cavernous nerve injury (CNI). Multipotent stromal cells (MSCs) are an attractive cell source for this application based on their regenerative potential and their clinical applicability. Aim. To review available evidence on the efficacy and mechanisms of action of MSC application for the treatment of ED, with an emphasis on ED following CNI. Methods. A nonsystematic review was conducted on the available English literature between 1966 and 2011 on the search engines SciVerse-sciencedirect, SciVerse-scopus, Google Scholar, and PubMed. Results. MSCs from both bone marrow and adipose tissue have shown beneficial effects in a variety of animal models for ED. While MSC application in chronic disease models such as diabetes, aging, and hyperlipidemia may result in cell engraftment and possibly MSC differentiation, this observation has not been made in the acute CNI rat model. In the latter setting, MSC effects seem to be established by cell recruitment toward the major pelvic ganglion and local paracrine interaction with the host neural tissue. Conclusions. While the type of model may influence the mechanisms of action of this MSC-based therapy, MSCs generally display efficacy in various animal models for ED. Before translation to the clinic is established, various hurdles need to be overcome.
机译：介绍。根治性前列腺切除术（RP）后的勃起功能障碍（ED）是由于疏忽靠近前列腺囊的海绵状神经造成的。 RP后ED发生的机制被越来越多的人认识，包括海绵体纤维化和海绵体平滑肌细胞凋亡，这是由于神经失用引起的海绵体神经变性所致。近年来，基于细胞的疗法因其在海绵状神经损伤（CNI）后恢复勃起功能的潜力而受到越来越多的关注。基于多能基质细胞（MSC）的再生潜力和临床适用性，它是此应用程序的诱人细胞来源。目标。审查有关MSC治疗ED的功效和作用机制的可用证据，重点是CNI后的ED。方法。在1966年至2011年之间，对搜索引擎SciVerse-sciencedirect，SciVerse-scopus，Google Scholar和PubMed上的可用英语文献进行了非系统性审查。结果。骨髓和脂肪组织的MSC在多种ED动物模型中均显示出有益的作用。尽管MSC在慢性疾病模型（例如糖尿病，衰老和高脂血症）中的应用可能会导致细胞植入并可能导致MSC分化，但在急性CNI大鼠模型中尚未进行此观察。在后一种情况下，似乎可以通过向主要骨盆神经节募集细胞以及与宿主神经组织发生局部旁分泌相互作用来建立MSC效应。结论。尽管模型的类型可能会影响这种基于MSC的疗法的作用机制，但MSC通常在各种动物模型中表现出ED的功效。在建立到诊所的翻译之前，需要克服各种障碍。

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