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首页> 外文期刊>The journal of sexual medicine >Erectile dysfunction precedes and is associated with severity of coronary artery disease among Asian Indians
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Erectile dysfunction precedes and is associated with severity of coronary artery disease among Asian Indians

机译：在亚洲印第安人中，勃起功能障碍先发并与冠状动脉疾病的严重程度相关

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Introduction: Erectile dysfunction (ED) and coronary artery disease (CAD) often share common risk factors, and there is growing evidence that ED might serve as a clinical marker for cardiovascular disease. Despite rising trends of CAD in Asian Indians, limited data are available on the prevalence of ED and its correlation with CAD severity in such patients. Aim: To study the prevalence of ED in Asian Indian patients undergoing coronary angiography and to assess if the severity of ED correlates with angiographic severity of CAD. Methods: In all patients undergoing coronary angiography, ED was assessed using the International Index of Erectile Function-5 questionnaire. Main Outcome Measures and Results: Among 175 male patients, ED was present in 70%; patients with ED had a higher incidence of multivessel CAD (80% vs. 36%, P 0.001), diffuse CAD (81% vs. 34%, P 0.001), and higher number of mean coronary vessels involved compared with those without ED. Those with severe ED had higher prevalence of multivessel CAD and higher number of mean coronary vessels involved compared with those with milder grades of ED. Onset of symptoms of ED preceded symptoms of CAD by a mean of 24.6 months in 84% of patients. The presence of severe ED was associated with a 21-fold higher risk of having triple-vessel disease (odds ratio [OR] 21.94, 95% confidence interval [CI] 3.41-141.09, P=0.001) and an 18-fold higher risk of having diffuse angiographic CAD (OR 17.91, 95% CI 3.11-111.09, P=0.001). Conclusion: Asian Indians with angiographic CAD frequently have ED; symptoms of ED precede that of CAD in most patients. Incidence of multivessel and diffuse CAD is significantly more common in patients with ED. It is important for physicians to be aware of the close relationship between the two conditions so that patients with ED can have optimal risk stratification for concomitant CAD whenever required.
机译：简介：勃起功能障碍（ED）和冠状动脉疾病（CAD）通常具有共同的危险因素，并且越来越多的证据表明ED可以作为心血管疾病的临床标志。尽管亚洲印第安人中CAD的趋势呈上升趋势，但有关此类患者中ED的患病率及其与CAD严重程度的相关性的数据有限。目的：研究亚洲印度裔冠状动脉造影患者中ED的患病率，并评估ED的严重程度是否与CAD的血管造影严重程度相关。方法：在所有接受冠状动脉造影的患者中，使用国际勃起功能指数5问卷对ED进行评估。主要结果指标和结果：在175名男性患者中，ED的发生率为70％。与没有ED的患者相比，ED的多血管CAD的发生率更高（80％比36％，P 0.001），弥漫性CAD（81％相对34％，P 0.001），平均冠状动脉介入的发生率更高。 ED较重度ED较轻者，多血管CAD患病率更高，平均受累冠状动脉数量也更高。在84％的患者中，ED的发作平均比CAD的症状早24.6个月。严重ED的存在与三支血管疾病的风险高21倍相关（比值比[OR] 21.94，95％置信区间[CI] 3.41-141.09，P = 0.001），风险高18倍。具有弥散性血管造影CAD（OR 17.91，95％CI 3.11-111.09，P = 0.001）。结论：亚洲印度裔患有血管造影CAD的人经常患有ED;在大多数患者中，ED的症状先于CAD。多血管和弥漫性CAD的发生率在ED患者中更为普遍。对医生而言，重要的是要意识到这两种情况之间的密切关系，以使ED患者在需要时可以对伴随CAD进行最佳风险分层。

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