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首页> 外文期刊>The journal of sexual medicine >Analysis of Erectile Responses to BAY 41-8543 and Muscarinic Receptor Stimulation in the Rat
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Analysis of Erectile Responses to BAY 41-8543 and Muscarinic Receptor Stimulation in the Rat

机译：大鼠对BAY 41-8543的勃起反应和毒蕈碱受体刺激的分析

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Introduction. Soluble guanylate cyclase (sGC) is the receptor for nitric oxide (NO) and in pathophysiologic conditions where NO formation or bioavailability is impaired, erectile dysfunction (ED) occurs. Aim. The aim of this study was to investigate erectile responses to the sGC stimulator BAY 41-8543 in physiologic and pathophysiologic conditions. Methods. Increases in intracavernosal pressure (ICP) in response to intracavernosal (ic) injections of BAY 41-8543 were investigated in the anesthetized rat. Main Outcome Measures. Increases in ICP/MAP in response to ic injections of BAY 41-8543 and the interaction of BAY 41-8543 with exogenous and endogenously released NO were investigated and the effect of the sGC stimulator on cavernosal nerve injury was assessed. The mechanism of the increase in ICP/MAP in response to ic injection of acetylcholine was investigated. Results. The ic injections of BAY 41-8543 increased ICP/MAP and the duration of the response. BAY 41-8543 was less potent than sodium nitroprusside (SNP) and ic injections of BAY 41-8543 and SNP produced a larger response than the algebraic sum of responses to either agent alone. Simultaneous ic injection of BAY 41-8543 and cavernosal nerve stimulation produced a greater response than either intervention alone. Atropine and cavernosal nerve crush injury decreased the response to nerve stimulation and ic injection of BAY 41-8543 restored the response. Conclusion. These data show that BAY 41-8543 has significant erectile activity and can synergize with exogenous and endogenously released NO. This study shows that atropine and nerve crush attenuate the response to cavernosal nerve stimulation and that BAY 41-8543 can restore the response. The results with atropine, L-NAME and hexamethonium indicate that the response to ic injection of acetylcholine is mediated by muscarinic receptors and the release of NO with no significant role for nicotinic receptors. These results suggest that BAY 41-8543 would be useful in the treatment of ED. Lasker GF, Pankey EA, Allain AV, Dhaliwal JS, Stasch J-P, Murthy SN, and Kadowitz PJ. Analysis of erectile responses to BAY 41-8543 and muscarinic receptor stimulation in the rat. J Sex Med 2013;10:704-718. ? 2012 International Society for Sexual Medicine.
机译：介绍。可溶性鸟苷酸环化酶（sGC）是一氧化氮（NO）的受体，在病理生理条件下（NO形成或生物利用度受损），会出现勃起功能障碍（ED）。目标。这项研究的目的是在生理和病理生理状况下研究对sGC刺激物BAY 41-8543的勃起反应。方法。在麻醉的大鼠中，研究了腔内注射BAY 41-8543引起的腔内压力（ICP）升高。主要观察指标。研究了IC注射BAY 41-8543引起的ICP / MAP升高以及BAY 41-8543与外源性和内源性释放的NO的相互作用，并评估了sGC刺激剂对海绵体神经损伤的作用。研究了ic / ic注射乙酰胆碱后ICP / MAP升高的机理。结果。 BAY 41-8543的ic注射增加了ICP / MAP和反应的持续时间。 BAY 41-8543的效力不及硝普钠（SNP），IC注射BAY 41-8543和SNP产生的应答要比对任何一种单独代理的应答的代数和大。与单独的任何一种干预措施相比，同时IC注射BAY 41-8543和海绵体神经刺激产生的反应更大。阿托品和海绵体神经挤压损伤降低了对神经刺激的反应，IC注射BAY 41-8543恢复了反应。结论。这些数据表明BAY 41-8543具有显着的勃起活性，并且可以与外源性和内源性释放的NO协同作用。这项研究表明，阿托品和神经挤压会减弱对海绵体神经刺激的反应，BAY 41-8543可以恢复这种反应。阿托品，L-NAME和六甲铵的结果表明，ic注射乙酰胆碱的反应是由毒蕈碱受体介导的，NO的释放对烟碱受体没有明显作用。这些结果表明BAY 41-8543将在ED的治疗中有用。 Lasker GF，Pankey EA，Allain AV，Dhaliwal JS，Stasch J-P，Murthy SN和Kadowitz PJ。大鼠勃起对BAY 41-8543的反应和毒蕈碱受体刺激的分析。 J Sex Med 2013; 10：704-718。 ？ 2012年国际性医学学会。

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