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首页> 外文期刊>The journal of sexual medicine >The effect of statins on erectile dysfunction: A meta-analysis of randomized trials
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The effect of statins on erectile dysfunction: A meta-analysis of randomized trials

机译：他汀类药物对勃起功能障碍的影响：一项随机试验的荟萃分析

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Introduction: Erectile dysfunction (ED) is common in older men, especially those with comorbidities such as diabetes and atherosclerotic disease, conditions where statins are frequently prescribed. Aim: To examine the effect of statin therapy on ED using the five-item version of the International Inventory of Erectile Function (IIEF). Methods: We performed a random-effects meta-analysis of studies identified by a systematic search of MEDLINE, Web of Knowledge, the Cochrane Database, and ClinicalTrials.gov. Examination of the 186 retrieved citations resulted in the selection of 11 randomized trials for inclusion in the meta-analysis. Main Outcome Measures: Change in the IIEF score. Results: IIEF increased by 3.4 points (95% CI 1.7-5.0, P=0.0001) with statins compared to control. This effect remained statistically significant after multiple sensitivity analyses, including analysis for publication bias, a cumulative meta-analysis, and 11 repeated analyses with each study omitted sequentially. The increase in IIEF with statins was approximately one-third to one-half of that previously reported with phosphodiesterase-5 inhibitors and larger than the effect of lifestyle modification. Metaregression showed an increase in benefit with decreasing lipophilicity. The average age of participants and the degree of LDL cholesterol lowering did not alter the effect on IIEF. Conclusion: Statins cause a clinically relevant improvement of erectile function as measured by the five-item version of the IIEF.
机译：简介：勃起功能障碍（ED）在老年男性中很常见，尤其是那些合并症，例如糖尿病和动脉粥样硬化疾病，经常服用他汀类药物的情况。目的：使用国际勃起功能清单（IIEF）的五项版本，检查他汀类药物治疗对ED的作用。方法：我们对MEDLINE，Web of Knowledge，Cochrane数据库和ClinicalTrials.gov进行系统搜索，对研究进行了随机效应荟萃分析。对186条检索到的引文进行检查后，选择了11项随机试验纳入荟萃分析。主要结果指标：IIEF得分变化。结果：与对照组相比，他汀类药物的IIEF增加了3.4点（95％CI 1.7-5.0，P = 0.0001）。经过多次敏感性分析（包括出版物偏倚分析，累积荟萃分析和11次重复分析）后，此效果在统计学上仍具有显着意义，其中每个研究均被依次省略。他汀类药物引起的IIEF升高约为以前报道的磷酸二酯酶5抑制剂的三分之一至二分之一，大于生活方式改变的影响。元回归显示，亲脂性降低会增加益处。受试者的平均年龄和LDL胆固醇降低的程度并未改变对IIEF的影响。结论：他汀类药物可导致临床上勃起功能的改善，如IIEF的五项测量。

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