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首页> 外文期刊>The journal of sexual medicine >A prospective study on association of prostatic calcifications with sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)
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A prospective study on association of prostatic calcifications with sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

机译：慢性前列腺炎/慢性盆腔疼痛综合征（CP / CPPS）男性前列腺钙化与性功能障碍相关性的前瞻性研究

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Introduction: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common debilitating condition of unclear etiology. Sexual dysfunction is an important component of the clinical phenotype of CP/CPPS. Patients often have prostatic calcifications, but a link to sexual dysfunction is unknown. Aim: The aim of this study was to evaluate the association of prostatic calcifications with sexual dysfunction in this condition. Methods: A total of 358 males with CP/CPPS were consecutively enrolled, and a prospectively maintained database of these patients was analyzed. Calcifications were diagnosed using ultrasound imaging of the prostate. Symptom severity was measured using the National Institutes of Health Chronic Prostatitis Symptom Index (CPSI). Sexual dysfunction was evaluated using the validated 15-item International Index of Erectile Function (IIEF-15) questionnaire and 5-item Premature Ejaculation Diagnostic Tool scales. The variables were compared between patients with prostatic calcifications and those without using the Student's t-test, Wilcoxon unpaired test, or chi-square test. Main Outcome Measure: Logistic regression models were developed to explore a possible association between prostatic calcifications and sexual dysfunction. Results: Measurable calcifications in the prostate were found in 175 (48.9%) of the 358 patients. Patients with calcifications were more likely to have higher white blood cell counts or positive bacteria cultures in their prostatic fluid, longer symptoms duration, and lower scores for the total IIEF-15, IIEF-erectile function, and IIEF-intercourse satisfaction domains (P<0.001 for each). However, the scores for CPSI, premature ejaculation, and IIEF-orgasmic function, IIEF-sexual desire, and IIEF-overall satisfaction domains were identical between men with and without calcifications (P>0.05 for each). Furthermore, logistic regression analyses revealed that intraprostatic calcification is significantly associated with self-assessed erectile dysfunction (ED) (odds ratio:3.632, 95% confidence interval: 2.405-5.822, P<0.001). Conclusion: Our results showed that prostatic calcifications are significantly associated with the presence of ED in CP/CPPS males.
机译：简介：慢性前列腺炎/慢性盆腔疼痛综合征（CP / CPPS）是病因不明的常见致残性疾病。性功能障碍是CP / CPPS临床表型的重要组成部分。患者常有前列腺钙化，但与性功能障碍的联系尚不清楚。目的：本研究的目的是评估在这种情况下前列腺钙化与性功能障碍的关系。方法：总共358名CP / CPPS男性患者被连续纳入，并分析了这些患者的前瞻性数据库。使用前列腺的超声成像诊断钙化。使用美国国立卫生研究院慢性前列腺炎症状指数（CPSI）测量症状的严重程度。使用经验证的15项国际勃起功能指数（IIEF-15）问卷和5项早泄诊断工具量表评估性功能障碍。比较了前列腺钙化患者与未使用学生t检验，Wilcoxon非配对检验或卡方检验的患者之间的变量。主要指标：开发了Logistic回归模型以探讨前列腺钙化与性功能障碍之间的可能联系。结果：358例患者中有175例（48.9％）发现了前列腺中可测量的钙化。钙化患者的前列腺液中更可能有更高的白细胞计数或阳性细菌培养，更长的症状持续时间以及更低的IIEF-15，IIEF-勃起功能和IIEF-性交满意度总分（P <每个0.001）。然而，有钙化和无钙化的男性之间的CPSI，早泄和IIEF-性高潮功能，IIEF-性欲和IIEF-总体满意度得分均相同（每人P> 0.05）。此外，逻辑回归分析显示，前列腺内钙化与自我评估的勃起功能障碍（ED）显着相关（比值：3.632，95％置信区间：2.405-5.822，P <0.001）。结论：我们的结果表明，CP / CPPS男性中前列腺钙化与ED的存在显着相关。

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