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首页> 外文期刊>The journal of sexual medicine >Long-Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health-Related Quality of Life
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Long-Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health-Related Quality of Life

机译：患有睾丸功能减退和勃起功能障碍的老年男性的长期睾丸激素治疗可降低肥胖症参数并改善代谢综合征和健康相关的生活质量

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Introduction Late-onset hypogonadism (LOH) is diagnosed when declining testosterone concentrations in the aging male cause unwanted symptoms such as erectile dysfunction (ED), reduced bone density and muscle strength, and increased visceral obesity. Testosterone deficiency is also associated with insulin resistance and the metabolic syndrome (MetS). Restoring testosterone to physiological concentrations has beneficial effects on many of these symptoms; however, it is not known whether these effects can be sustained in the long term. Aims To investigate whether treatment with testosterone undecanoate (TU) has a long-term and sustained effect on parameters affected by the MetS in men with LOH and ED, to determine whether long-term testosterone treatment can improve the overall health-related quality of life in these men, and to establish the safety of long-term testosterone treatment. Methods Two hundred sixty-one patients (mean age 59.5 +/- 8.4 years) diagnosed with LOH and ED were treated with long-acting TU in a prospective, observational, and longitudinal registry study. Men received intramuscular injections of 1,000mg TU at day 1, at week 6, and every 3 months thereafter. Main Outcome Measures Parameters affected by the MetS, including obesity parameters (body weight, waist circumference, and body mass index [BMI]), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, HbA1c (glycated hemoglobin), and blood pressure, as well as total testosterone levels and health-related quality of life, were assessed. Results We found TU significantly improved obesity parameters (body weight, waist circumference, and BMI) and lowered total cholesterol, LDL cholesterol, triglycerides, fasting blood glucose, HbA1c, and blood pressure over the 5-year study. HDL cholesterol was increased. TU treatment resulted in a sustained improvement in erectile function and muscle and joint pain, which contributed to an improvement in long-term health-related quality of life. Furthermore, we found a relationship between health-related quality of life and waist circumference. Finally, we found no evidence that long-term treatment with TU increases the risk of prostate carcinoma. Conclusion Long-term TU in men with LOH and ED reduces obesity parameters and improves metabolic syndrome and health-related quality of life. Yassin DJ, Doros G, Hammerer PG, and Yassin AA. Long-term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and health-related quality of life. J Sex Med 2014;11:1567-1576.
机译：简介衰老男性中睾丸激素浓度下降会导致勃起功能障碍（ED），骨密度和肌肉力量降低以及内脏肥胖增加等不良症状，从而诊断为迟发性腺功能减退（LOH）。睾丸激素缺乏症也与胰岛素抵抗和代谢综合征（MetS）有关。恢复睾丸激素至生理浓度对这些症状有很多有益作用。但是，尚不清楚这些效果是否可以长期维持。目的探讨用十一酸睾丸激素（TU）治疗对LOH和ED男性中受MetS影响的参数是否具有长期持续影响，以确定长期睾丸激素治疗是否可以改善总体健康相关生活质量在这些男性中，并建立长期睾丸激素治疗的安全性。方法在一项前瞻性，观察性和纵向登记研究中，对261例诊断为LOH和ED的患者（平均年龄59.5 +/- 8.4岁）进行了长效TU治疗。男性在第1天，第6周和此后每3个月接受1,000 mg TU的肌内注射。主要结果指标受MetS影响的参数，包括肥胖参数（体重，腰围和体重指数[BMI]），总胆固醇，低密度脂蛋白（LDL），高密度脂蛋白（HDL），甘油三酸酯，葡萄糖评估HbA1c（糖化血红蛋白）和血压，以及总睾丸激素水平和与健康相关的生活质量。结果在为期5年的研究中，我们发现TU显着改善了肥胖参数（体重，腰围和BMI），并降低了总胆固醇，LDL胆固醇，甘油三酸酯，空腹血糖，HbA1c和血压。 HDL胆固醇升高。 TU治疗导致勃起功能以及肌肉和关节疼痛的持续改善，从而改善了与健康相关的长期生活质量。此外，我们发现与健康相关的生活质量与腰围之间存在关系。最后，我们没有发现长期使用TU可以增加前列腺癌风险的证据。结论LOH和ED男性的长期TU可以降低肥胖参数，改善代谢综合征和健康相关的生活质量。 Yassin DJ，Doros G，Hammerer PG和Yassin AA。对患有性腺功能低下和勃起功能障碍的老年男性进行长期睾丸激素治疗可以减少肥胖症参数，改善代谢综合征和健康相关的生活质量。 J Sex Med 2014; 11：1567-1576。

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