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Sildenafil Increases the p50 and Shifts the Oxygen-Hemoglobin Dissociation Curve to the Right

机译:西地那非可增加p50并向右移动氧合血红蛋白的解离曲线

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IntroductionSildenafil (Viagra (R)) is a selective phosphodiesterase type 5 (PDE5) inhibitor that block the breakdown of cyclic guanyl monophosphate (cGMP) leading to relaxation of the smooth muscles of the corpus cavernous and an increase in blood flow resulting in penile erection. It is hypothesized that sildenafil will increase the release of oxygen from erythrocytes and shift the oxygen-hemoglobin curve to the right.
机译:简介西地那非(Viagra(R))是一种选择性5型磷酸二酯酶(PDE5)抑制剂,可阻断环状单磷酸鸟苷(cGMP)的分解,从而导致海绵体平滑肌松弛和血流量增加,从而导致阴茎勃起。假设西地那非会增加红细胞中氧气的释放并使氧气-血红蛋白曲线向右移动。

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