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首页> 外文期刊>The Korean Journal of Genetics >Expression Patterns of Immune Related Genes in Th1 and Th2 Cells Revealed by Microarray Analysis
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Expression Patterns of Immune Related Genes in Th1 and Th2 Cells Revealed by Microarray Analysis

机译：芯片分析显示Th1和Th2细胞中免疫相关基因的表达模式

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T helper cells play a distinct role in activating and regulating immune responses. Th1 cells mediate cellular immunity by activating macrophages, whereas Th2 cells mediate humoral immunity by activating B cells. The differentiation of Thl and Th2 cells accompany drastic changes in immune function, cellular metabolism, gene expression, chromatin structure, and cell morphology. To search for more information on the immune functions of Th1 and Th2 cells, we examined a gene expression profile in immune related genes by microarray analysis. As expected many differentiation-specific cytokine, chemokine, and transcription factor genes are differentially expressed. I also discovered that a group of interferon-regulated genes is selectively expressed in Th1cells, and that a group of immunoglobulin genes and various types of cell surface receptors are selectively expressed in Th2 cells. These studies extend the current understanding of immune function of T helper cells and find more molecules involved in the T helper cell differentiation.
机译：T辅助细胞在激活和调节免疫应答中起着独特的作用。 Th1细胞通过激活巨噬细胞来介导细胞免疫，而Th2细胞通过激活B细胞来介导体液免疫。 Th1和Th2细胞的分化伴随着免疫功能，细胞代谢，基因表达，染色质结构和细胞形态的急剧变化。为了搜索有关Th1和Th2细胞免疫功能的更多信息，我们通过微阵列分析检查了免疫相关基因中的基因表达谱。如预期的那样，许多分化特异性细胞因子，趋化因子和转录因子基因被差异表达。我还发现，一组干扰素调节的基因在Th1细胞中选择性表达，并且一组免疫球蛋白基因和各种类型的细胞表面受体在Th2细胞中选择性表达。这些研究扩展了当前对T辅助细胞免疫功能的了解，并发现了更多与T辅助细胞分化有关的分子。

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