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首页> 外文期刊>The journal of sexual medicine >Pulse pressure, an index of arterial stiffness, is associated with androgen deficiency and impaired penile blood flow in men with ED.
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Pulse pressure, an index of arterial stiffness, is associated with androgen deficiency and impaired penile blood flow in men with ED.

机译：脉压是动脉硬化的指标，与ED男性雄激素缺乏和阴茎血流受损有关。

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INTRODUCTION: Pulse pressure (PP; i.e., the arithmetic difference between systolic and diastolic blood pressure) reflects arterial stiffness and has been suggested to be an independent cardiovascular risk factor. AIM: The aim of the present study is to asses the possible contribution of PP to arteriogenic erectile dysfunction (ED) and ED-associated hypogonadism. METHODS: A consecutive series of 1,093 (mean age 52.1 +/- 13.0 years) male patients with ED and without a previous history of hypertension or not taking any antihypertensive drugs were investigated. MAIN OUTCOME MEASURES: Several hormonal and biochemical parameters were studied, along with structured interview on erectile dysfunction (SIEDY), ANDROTEST structured interviews, and penile Doppler ultrasound. RESULTS: Subjects with higher PP quartiles showed worse erectile function and higher prevalence of arteriogenic ED even after adjustment for confounding factors. Furthermore, sex hormone binding globulin-unbound testosterone levels declined as a function of PP quartiles. Accordingly, the prevalence of overt hypogonadism (calculated free testosterone < 180 pmol/L or free testosterone < 37 pmol/L) increased as a function of PP quartiles (17.% vs. 39.7%, and 30.8% vs. 58.6% for the first vs. fourth quartile, respectively, for calculated free testosterone and free testosterone; all P < 0.0001 for trend). This association was confirmed even after adjustment for confounders (Adjusted [Adj]) r = 0.090 and 0.095 for calculated free testosterone < 180 pmol/L and free testosterone < 37 pmol/L, respectively; all P < 0.05). CONCLUSIONS: PP is an easy method to estimate and quantify patient arterial stiffness. We demonstrated here for the first time that elevated PP is associated with arteriogenic ED and male hypogonadism. The calculation of PP should became more and more familiar in the clinical practice of health care professionals involved in sexual medicine.
机译：简介：脉压（PP;即收缩压和舒张压之间的算术差异）反映了动脉僵硬，已被认为是独立的心血管危险因素。目的：本研究的目的是评估PP对动脉源性勃起功能障碍（ED）和ED相关性腺功能减退的可能作用。方法：调查了连续1 093例（平均年龄52.1 +/- 13.0岁）ED且无高血压史或未服用任何降压药的男性患者。主要观察指标：研究了几种激素和生化参数，以及对勃起功能障碍的结构性访谈（SIEDY），ANDROTEST结构性访谈和阴茎多普勒超声。结果：即使校正混杂因素，PP四分位数较高的受试者仍表现出较差的勃起功能和较高的动脉源性ED患病率。此外，性激素结合球蛋白未结合的睾丸激素水平随着PP四分位数的下降而下降。因此，明显的性腺功能减退症的患病率（计算得出的游离睾丸激素<180 pmol / L或游离睾丸激素<37 pmol / L）随PP四分位数的增加而增加（17.％vs. 39.7％，30.8％vs. 58.6％）。计算的游离睾丸激素和游离睾丸激素分别为第一个四分位数与第四个四分位数;趋势的所有P <0.0001）。即使对混杂因素进行了调整（校正[调整]），这种联系也得到了证实。计算出的游离睾丸激素<180 pmol / L和游离睾丸激素<37 pmol / L的r分别为0.090和0.095。所有P <0.05）。结论：PP是一种简单的方法来估计和量化患者的动脉僵硬度。我们在这里首次证明PP升高与动脉粥样硬化性ED和男性性腺功能减退有关。在涉及性医学的卫生保健专业人员的临床实践中，PP的计算应变得越来越熟悉。

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