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首页> 外文期刊>The journal of sexual medicine >Circulating CD34+ KDR+ endothelial progenitor cells correlate with erectile function and endothelial function in overweight men.
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Circulating CD34+ KDR+ endothelial progenitor cells correlate with erectile function and endothelial function in overweight men.

机译：超重男性中循环中的CD34 + KDR +内皮祖细胞与勃起功能和内皮功能相关。

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INTRODUCTION: Bone marrow-derived endothelial progenitor cells (EPCs) circulate in the peripheral blood and are involved in endothelial homeostasis and repair. AIM: The aim of this study was to assess the circulating levels of different EPC phenotypes in overweight men with or without erectile dysfunction (ED). As endothelial dysfunction is considered a necessary link with ED, endothelium-dependent vasodilation and its relation with EPCs were also investigated. METHODS: We studied 30, otherwise healthy, overweight subjects with symptomatic ED for at least 6 months, and 30 age- and weight-matched subjects without ED. Erectile function was assessed by completing the International Index of Erectile Function (IIEF-5), which consists of items 5, 15, 4, 2, and 7 from the full-scale IIEF-15. MAIN OUTCOME MEASURES: Seven subpopulations of EPCs were determined by flow cytometry on the basis of the surface expression of CD34, CD133, and KDR antigens: CD34(+), CD133(+), KDR(+), CD34(+)CD133(+), CD34(+)KDR(+), CD133(+)KDR(+), and CD34(+)CD133(+)KDR(+). Endothelium-dependent flow-mediated dilation (FMD) was evaluated in the right brachial artery with a high-resolution ultrasound machine following reactive hyperemia. RESULTS: CD34(+)KDR(+) cell count was significantly lower in men with ED as compared with men without ED (63.1 +/- 4 vs. 92.4 +/- 6 cells/10(6) events, mean +/- standard error, P < 0.01). There was a significant direct correlation between circulating CD34(+)KDR(+) cells and the IIEF score (r = 0.44; P = 0.01): men with the severe form of ED presented the lowest level of circulating EPC CD34(+)KDR(+) cells. No significant correlation was found between the circulating levels of the other EPC phenotypes and the IIEF score. There was a significant correlation between CD34(+)KDR(+) cell count and FMD (r = 0.45; P = 0.01), but not between FMD and the other phenotypes. CONCLUSIONS: Circulating levels of CD34(+)KDR(+) EPC are reduced in overweight subjects with ED and correlate with the severity of ED. Other EPC phenotypes are not related to ED, suggesting that the CD34(+)KDR(+) phenotype of EPCs may be preferred in future studies.
机译：简介：骨髓来源的内皮祖细胞（EPC）在外周血中循环，并参与内皮的稳态和修复。目的：本研究的目的是评估有或没有勃起功能障碍（ED）的超重男性中不同EPC表型的循环水平。由于内皮功能障碍被认为是与ED的必要联系，因此还研究了内皮依赖性血管舒张及其与EPC的关系。方法：我们研究了30例健康的，超重的有症状ED的受试者至少6个月，以及30例年龄和体重匹配的无ED的受试者。通过完成国际勃起功能指数（IIEF-5）评估勃起功能，该指数由全额IIEF-15的项目5、15、4、2和7组成。主要观察指标：根据CD34，CD133和KDR抗原的表面表达，通过流式细胞术确定了EPC的七个亚群：CD34（+），CD133（+），KDR（+），CD34（+）CD133（ +），CD34（+）KDR（+），CD133（+）KDR（+）和CD34（+）CD133（+）KDR（+）。反应性充血后，使用高分辨率超声仪在右臂肱动脉中评估内皮依赖性血流介导的扩张（FMD）。结果：与没有ED的男性相比，患有ED的男性的CD34（+）KDR（+）细胞计数显着降低（63.1 +/- 4 vs. 92.4 +/- 6细胞/ 10（6）事件，平均+/-标准误差，P <0.01）。循环的CD34（+）KDR（+）细胞与IIEF评分之间存在显着的直接相关性（r = 0.44; P = 0.01）：ED严重形式的男性循环EPC CD34（+）KDR的水平最低（+）个单元格。在其他EPC表型的循环水平与IIEF评分之间未发现显着相关性。 CD34（+）KDR（+）细胞计数与FMD之间存在显着相关性（r = 0.45; P = 0.01），但FMD与其他表型之间无显着相关性。结论：超重的ED患者中CD34（+）KDR（+）EPC的循环水平降低，并且与ED的严重程度相关。其他EPC表型与ED不相关，这表明EPC的CD34（+）KDR（+）表型可能在以后的研究中被优先使用。

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