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首页> 外文期刊>The Korean Journal of Genetics >An insertion polymorphism of LY1 retroposon in east Asians and its implications for the population studies of Koreans
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An insertion polymorphism of LY1 retroposon in east Asians and its implications for the population studies of Koreans

机译：LY1逆转录子在东亚地区的插入多态性及其对韩国人口研究的启示。

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摘要

We have examined a polymorphic LY1 retroposon insertion in the centromeric alphoid array of the Y-chromosome in samples from a total of 662 unrelated males from several ethnic groups of east Asia. The LY1 insertion polymorphism was detected by PCR amplification using flanking primers of the L1-alphoid junction, and electrophoresis on denaturing polyacrylamide gels followed by silver staining. Although the LY1 insertion frequencies varied among Chinese samples (mean: 6.0 percent), it was present athigh frequencies in samples of the Miao (25.0 percent) and Han Chinese (21.4 percent), followed by Koreans (10.1 percent), Mongolians (8.8 percent), and Japanese (1.6 percent). This pattern of observed variation is similar to other recent surveys where it was found to be at the highest frequency in China, and was present at low frequencies in the surrounding areas, but most Caucasian and Negroid males examined so far completely lack the LY1 retroposon insertion. These findings would lead us to considertwo possible explanations that Koreans are more likely related to the Chinese than to other east Asians, or that it is evidence of drift within the Korean population. The distribution pattern of LY1 insertion frequencies also reflected a common genetic affinity in contemporary populations from Korea and other parts of east Asia.
机译：我们检查了来自东亚几个种族的662名无亲缘关系的男性的样本中Y染色体着丝粒体摆形的多态性LY1逆转录子插入。 LY1插入的多态性是通过使用L1-脂质连接的侧翼引物进行PCR扩增来检测的，并在变性聚丙烯酰胺凝胶上进行电泳，然后进行银染。尽管LY1插入频率在中国样本中有所不同（平均：6.0％），但在苗族（25.0％）和汉族（21.4％）样本中出现的频率很高，其次是韩国人（10.1％），蒙古人（8.8％）。 ）和日语（1.6％）。这种观察到的变异的模式与其他最近的调查相似，在中国发现其发生频率最高，并且在周边地区以较低的频率出现，但是到目前为止，大多数接受检查的白人和黑人男性完全没有LY1逆转录子插入。这些发现将使我们考虑两种可能的解释，即韩国人与中国人的关系要比其他东亚人的可能性大，或者这是韩国人口内部漂移的证据。 LY1插入频率的分布模式还反映了韩国和东亚其他地区当代人群的常见遗传亲和力。

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