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首页> 外文期刊>The Korean Journal of Parasitology >Genotype and animal infectivity of a human isolate of Cryptosporidium parvum in the Republic of Korea
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Genotype and animal infectivity of a human isolate of Cryptosporidium parvum in the Republic of Korea

机译：大韩民国隐孢子虫分离株的基因型和动物感染性

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摘要

Cryptosporidium parvum oocysts were isolated from a child suffering from acute gastroenteritis and successfully passaged in a calf and mice (designated hereafter SNU-H1) in the Republic of Korea; its molecular genotype has been analyzed. The GAG microsatellite region was amplified by a polymerase chain reaction (PCR), with a 238 base pair product, which is commonly displayed in C. parvum. The isolate was shown to be a mixture of the genotypes 1 (anthroponotic) and 2 fzoonotic). To study its infectivity in animals, 2 calves and 3 strains of mice were infected with the SNU-H1; in these animals, the propagation of both genotypes was successful. In immunosup-pressed (ImSP) BALB/c and C57BL/6 mice the number of oocysts decreased after day 10 post-infection (PI); but in ImSP ICR mice, they remained constant until day 27 PI. The results show that both the C. parvum genotypes 1 and 2 can be propagated in calves and ImSP mice.
机译：小隐隐孢子虫卵囊是从一名患有急性胃肠炎的儿童中分离出来的，并成功地在大韩民国的小牛和小鼠（以下称为SNU-H1）中传代。已经对其分子基因型进行了分析。 GAG微卫星区域通过聚合酶链式反应（PCR）扩增，并带有一个238个碱基对的产物，通常在小球藻中显示。该分离物显示为基因型1（人类）和2真核动物的混合物。为了研究其在动物中的感染性，用SNU-H1感染了2头牛犊和3株小鼠。在这些动物中，两种基因型的繁殖都是成功的。在免疫抑制（ImSP）的BALB / c和C57BL / 6小鼠中，感染后（PI）第10天后，卵囊的数量减少了。但是在ImSP ICR小鼠中，它们一直保持稳定，直到第27天。结果表明，小隐孢子虫基因型1和2均可在小牛和ImSP小鼠中繁殖。

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