Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.

Akiyama K; Iwaki T; Sugimoto N; Chardwiriyapreecha S; Kawano M; Nishimoto S; Sugahara T; Sekito T; Kakinuma Y

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Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.

机译：Bfr1p负责粟酒裂殖酵母中对三丁基锡的抗性。

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ATP-binding cassette (ABC) transporter plays an important role for resistance against xenobiotics. There are eleven ABC transporter genes in the genome of fission yeast Schizosaccharomyces pombe. We examined the role of ABC transporter against the toxicity of tributyltin chloride (TBT), a widespread environmental pollutant, in cell growth. Among individual ABC transporter mutants, the growth of a mutant deficient in Bfr1p, a plasma membrane-embedded transporter, was extremely sensitive to TBT. The lethal TBT concentration inducing 50% of cell death (LC(50)) was 25 microM for the parent strain and 10.2 microM for the bfr1 mutant. Thus, Bfr1p was responsible for TBT resistance in S. pombe.

机译：ATP结合盒（ABC）转运蛋白在抵抗异种生物方面起着重要作用。裂殖酵母粟酒裂殖酵母基因组中有11个ABC转运蛋白基因。我们检查了ABC转运蛋白对三丁基氯化锡（TBT）（一种广泛的环境污染物）在细胞生长中的毒性的作用。在单个的ABC转运蛋白突变体中，缺乏Bfr1p（质膜嵌入的转运蛋白）的突变体的生长对TBT极为敏感。导致50％细胞死亡的致命TBT浓度（LC（50））对于亲本菌株为25 microM，对于bfr1突变体为10.2 microM。因此，Bfr1p导致了粟酒裂殖酵母中的TBT抗性。

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《The Journal of toxicological sciences》 |2011年第1期|共4页
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Akiyama K; Iwaki T; Sugimoto N; Chardwiriyapreecha S; Kawano M; Nishimoto S; Sugahara T; Sekito T; Kakinuma Y;
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1. Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe. [J] . Akiyama K, Iwaki T, Sugimoto N, The Journal of toxicological sciences . 2011,第1期

机译：Bfr1p负责粟酒裂殖酵母中对三丁基锡的抗性。
2. Evidence that RNA polymerase II and not TFIIB is responsible for the difference in transcription initiation patterns between Saccharomyces cerevisiae and Schizosaccharomyces pombe. [J] . Yang C, Ponticelli AS Nucleic Acids Research . 2012,第14期

机译：RNA聚合酶II而非TFIIB导致酿酒酵母和粟酒裂殖酵母之间转录起始模式差异的证据。
3. Cloning and analysis of transcription of the mei2 gene responsible for initiation of meiosis in the fission yeast Schizosaccharomyces pombe. [J] . C Shimoda, M Uehira, M Kishida, Journal of bacteriology . 1987,第1期

机译：裂殖酵母粟酒裂殖酵母中负责减数分裂起始的mei2基因的克隆和分析。
4. Tributyltin(TBT)Resistance in Aeromonas veronii:Isolation of Gene(s)and Protein(s)Involved in TBT Resistance [C] . Andreia Cruz, Lisa Nonaka, Ana Domingos International Symposium Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes . 2007

机译：Aeromonas veronii的致杂丁醇（TBT）抗性：涉及TBT抗性的基因和蛋白质的分离
5. Genomic Approaches to Characterize Pre-mRNA Splicing Regulation in Schizosaccharomyces pombe. [D] . Larson, Amy. 2017

机译：表征粟酒裂殖酵母前mRNA剪接调控的基因组方法。
6. Cloning and analysis of transcription of the mei2 gene responsible for initiation of meiosis in the fission yeast Schizosaccharomyces pombe. [O] . C Shimoda, M Uehira, M Kishida, 1987

机译：裂殖酵母粟酒裂殖酵母中负责减数分裂启动的mei2基因的克隆和分析。
7. RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe. [O] . Masato Taoka, Daisuke Ishikawa, Yuko Nobe, 2014

机译：小亚基核糖体RNa的RNa胞苷乙酰转移酶：裂解酵母中的乙酰化位点和负责的乙酰转移酶的鉴定，裂殖酵母（schizosaccharomyces pombe）。
8. FINAL REPORT FACTORS RESPONSIBLE FOR RESISTANCE TO ENTERIC INFECTION THE ROLE OF THE INTESTINAL MICROFLORA IN RESISTANCE TO ENTERIC INFECTION [R] . C. Phillip Miller 1957

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Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.

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