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首页> 外文期刊>The Journal of toxicological sciences >Safety evaluation of a newly-developed dietary fiber: resistant glucan mixture
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Safety evaluation of a newly-developed dietary fiber: resistant glucan mixture

机译：新型膳食纤维：抗性葡聚糖混合物的安全性评估

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Resistant glucan mixture (RGM), a water-soluble dietary fiber produced by the random polymerization of glucose with activated carbon as a catalyst at a high temperature, has been recently developed by our group. There has been little physiological and safety research into RGM and therefore we now present our research into its safety. A reverse mutation assay indicated that RGM is not mutagenic either with or without metabolic activation. We conducted a 90-day subchronic oral toxicity study in rats. Male and female rats fed either a 3% or 5% w/w RGM diet had no muddy or watery stools, and there was no RGM-related death in any group. Although some parameters in the 3% and 5% w/w groups were significantly different from those in the control group, these changes were not due to any toxicity from RGM. The results indicated that the No Observed Adverse Effect Level (NOAEL) of RGM was 3.3 and 3.9 g/kg body weight (BW) per day in male and female rats, respectively. We then studied the gastrointestinal effects of RGM in healthy adult humans. Gastrointestinal symptoms, such as gurgling sounds, flatus and tenesmus, were mild and transient. In men and women, the maximum no-effect dose for diarrhea was more than 0.9 g RGM /kg BW. The results of our current safety assessment studies suggest that RGM is safe for human consumption.
机译：我们的小组最近开发了抗性葡聚糖混合物（RGM），它是通过葡萄糖与活性炭作为催化剂在高温下无规聚合而生产的水溶性膳食纤维。 RGM的生理和安全性研究很少，因此，我们现在介绍其安全性的研究。反向突变分析表明，无论有无代谢激活，RGM都不致突变。我们在大鼠中进行了为期90天的亚慢性口腔毒性研究。饲喂3％或5％w / w RGM饮食的雄性和雌性大鼠都没有浑浊或水样的粪便，并且在任何组中都没有与RGM相关的死亡。尽管3％和5％w / w组的某些参数与对照组相比有显着差异，但这些变化并不是由于RGM引起的任何毒性。结果表明，雄性和雌性大鼠的RGM的未观察到的不良反应水平（NOAEL）分别为每天3.3和3.9 g / kg体重（BW）。然后，我们研究了RGM对健康成年人的胃肠道作用。胃肠道症状，如咯咯的声音，肠胃气胀和里急后重，是轻度和短暂的。在男性和女性中，腹泻的最大无效剂量超过0.9 g RGM / kg BW。我们目前的安全评估研究结果表明，RGM可安全食用。

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