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首页> 外文期刊>The Journal of toxicological sciences >A repeated dose 28-day oral toxicity study of extract from cultured Lentinula edodes mycelia in Wistar rats.
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A repeated dose 28-day oral toxicity study of extract from cultured Lentinula edodes mycelia in Wistar rats.

机译：重复剂量的28天Wistar大鼠香菇菌丝体提取物的口服毒性研究。

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摘要

To evaluate the toxicological safety of extract from cultured Lentinula edodes mycelia (L.E.M.), repeated doses (2,000 mg/kg/day) were administered to male and female Wistar rats for 28 days. No mortality or abnormality in the general status or appearance was observed in rats administered L.E.M extract. Body weight and food consumption decreased slightly, particularly in the case of male rats, although the degree of decrease was not as prominent toward the end of administration. Examination of hematology, serum biochemistry, absolute and relative organ weights, autopsy and histopathology revealed only a few statistically significant differences between the treatment and control groups; these differences suggested no clinically significant changes related to toxicity. Consequently, the no observed adverse effect level (NOAEL) of L.E.M. extract was considered to be more than 2,000 mg/kg/day under the conditions of the present study.
机译：为了评价培养的香菇菌丝体（L.E.M.）提取物的毒理学安全性，对雄性和雌性Wistar大鼠重复给药28天（2,000 mg / kg /天）。在服用L.E.M提取物的大鼠中，未观察到一般状态或外观的死亡或异常。体重和食物消耗略有下降，特别是在雄性大鼠中，尽管下降的程度在给药结束时并不明显。血液学，血清生化，绝对和相对器官重量，尸检和组织病理学检查显示，治疗组和对照组之间只有少数统计学上显着的差异。这些差异表明没有与毒性相关的临床显着变化。因此，没有观察到L.E.M.的不良影响水平（NOAEL）。在本研究的条件下，提取物被认为超过2,000 mg / kg /天。

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