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首页> 外文期刊>The Journal of toxicological sciences >Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth
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Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

机译：自出生以来，铀会改变或不改变海马大鼠的行为和抗氧化状态

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摘要

In view of the known sensitivity of the developing central nervous system to pollutants, we sought to assess the effects of exposure to uranium (U) a heavy metal naturally present in the environment on the behavior of young rats and the impact of oxidative stress on their hippocampus. Pups drank U (in the form of uranyl nitrate) at doses of 10 or 40 mg.L-1 for 10 weeks from birth. Control rats drank mineral water. Locomotor activity in an open field and practice effects on a rotarod device decreased in rats exposed to 10 mg.L-1 (respectively, -19.4% and -51.4%) or 40 mg.L-1 (respectively, -19.3% and -55.9%) in compared with control rats. Anxiety (+37%) and depressive-like behavior (-50.8%) were altered by U exposure only at 40 mg.L-1. Lipid peroxidation (+35%) and protein carbonyl concentration (+137%) increased significantly after exposure to U at 40 mg.L-1. A significant increase in superoxide dismutase (SOD, +122.5%) and glutathione peroxidase (GPx, +13.6%) activities was also observed in the hippocampus of rats exposed to 40 mg.L-1. These results demonstrate that exposure to U since birth alters some behaviors and modifies antioxidant status..
机译：考虑到中枢神经系统对污染物的敏感性，我们试图评估暴露于环境中天然存在的重金属铀（U）对幼鼠行为及其氧化应激的影响。海马。幼崽从出生起十周内就以10或40 mg.L-1的剂量饮用U（硝酸铀酰）的形式。对照大鼠喝矿泉水。在暴露于10 mg.L-1（分别为-19.4％和-51.4％）或40 mg.L-1（分别为-19.3％和-）的大鼠中，空旷地的运动活动和对旋转仪的练习效果降低与对照组相比，占55.9％）。仅在40 mg.L-1下暴露于U即可改变焦虑（+ 37％）和抑郁样行为（-50.8％）。暴露于40 mg.L-1的U后，脂质过氧化（+ 35％）和蛋白质羰基浓度（+ 137％）显着增加。在暴露于40 mg.L-1的大鼠海马中也观察到超氧化物歧化酶（SOD，+ 122.5％）和谷胱甘肽过氧化物酶（GPx，+ 13.6％）活性的显着增加。这些结果表明，自出生以来暴露于U会改变某些行为并改变抗氧化剂的状态。

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