In order to prepare background data for toxicity studies, serum alkaline phosphatase activity in a total of 5,242 male and female beagle dogs was surveyed for the sequence of changes in activity through aging. About 95% of the beagle dogs surveyed were 5 to 12 months of age, corresponding with the age usually employed in toxicity studies. Serum alkaline phosphatase (ALP) activity, about 460IU/1 at 5 months of age, steadily decreased and reached a level about one third of that (about 160 IU/1) at 12 months of age, and remained unchanged thereafter. The above findings were essentially the same irrespective of sex and breeding colony. The present results are useful information in the evaluation of blood chemistry data in toxicity studies.
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机译：为了准备毒性研究的背景数据，调查了总计5,242只雄性和雌性比格犬的血清碱性磷酸酶活性，以了解其衰老过程中活性变化的顺序。接受调查的比格犬中约有95％的年龄为5至12个月大，与毒性研究中通常采用的年龄相对应。血清碱性磷酸酶（ALP）活性在5个月大时约460IU / 1，稳定下降并在12个月大时达到其水平的约三分之一（约160 IU / 1），此后保持不变。不论性别和繁殖群体，以上发现基本相同。目前的结果是在毒性研究中评估血液化学数据的有用信息。
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