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首页> 外文期刊>The Journal of toxicological sciences >Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity.
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Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity.

机译：使用遗传毒性，光毒性和促氧化剂活性的测试评估了水溶性富勒烯的生物安全性。

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摘要

We evaluated the safety of water-soluble polymer-enwrapped fullerenes (PVP/fullerenes) as antioxidants in cosmetic and pharmaceutical preparations by studying the genotoxicity, phototoxicity, and pro-oxidant effects of these fullerenes. These materials were not mutagenic to any of the tested bacterial strains and did not induce chromosomal aberrations in cultured mammalian cells. The PVP/fullerenes did not exhibit cytotoxicity under ultraviolet or sham irradiation in the alternative phototoxicity test. Moreover, they did not show any pro-oxidant effect in the presence of Fe(2+) or Cu(2+). Thus, we concluded that PVP/fullerenes are safe for use in cosmetic and pharmaceutical applications. This is the first study in which toxicity tests were performed on PVP/fullerenes.
机译：通过研究这些富勒烯的遗传毒性，光毒性和促氧化剂作用，我们评估了水溶性聚合物包裹的富勒烯（PVP /富勒烯）作为抗氧化剂在化妆品和药物制剂中的安全性。这些材料对任何测试的细菌菌株均不致突变，并且不会在培养的哺乳动物细胞中诱导染色体畸变。在替代的光毒性测试中，PVP /富勒烯在紫外线或深空照射下没有细胞毒性。此外，他们在Fe（2+）或Cu（2+）的存在下未显示任何促氧化剂作用。因此，我们得出结论，PVP /富勒烯可安全用于化妆品和制药应用。这是首次对PVP /富勒烯进行毒性测试的研究。

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