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首页> 外文期刊>The Journal of toxicological sciences >Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis.
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Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis.

机译：小鼠血清素（5-HT）3受体介导的固体胃排空是预测呕吐的简单标记。

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Nausea and emesis are often observed as side effects with many medicines and may lead to poor treatment compliance. In the present study, we aimed to establish simple methods for predicting nausea and/or emesis in mice, which do not vomit, using drugs and chemicals known to evoke nausea and/or emesis. The gastrointestinal transit test, the liquid gastric emptying by phenol red solution (Phenol red method) and the solid gastric emptying by resin beads (Beads method) were used and the effects of antispasmogenics (atropine, 0.1-3 mg/kg i.p.; salmon calcitonin, 1-30 units/kg i.m.), nauseants (copper sulfate, 1-30 mg/kg p.o.; apomorphine, 0.01-0.3 mg/kg s.c.) and chemotherapeutics (cisplatin, 0.3-10 mg/kg i.v.; doxorubicin, 0.3-10 mg/kg i.v.) were evaluated. In addition, the effects of ondansetron, a serotonin (5-HT)(3) receptor antagonist, on the inhibition of solid gastric emptying induced by salmon calcitonin, copper sulfate, cisplatin and doxorubicin were also assessed. Only the solid gastric emptying method could detect changes of gastric emptying by all drugs and chemicals. We also found that the inhibition of solid gastric emptying induced by cisplatin and doxorubicin was dose-dependently antagonized by ondansetron. However, ondansetron failed to antagonize the salmon calcitonin-induced delay, but exerted only very weak effects with copper sulfate. Solid gastric emptying may be more suitable than gastrointestinal intestinal transit or liquid gastric emptying in mice to predict nausea and/or emesis. Our results also suggest that chemotherapeutic-induced delay of solid gastric emptying mediated via 5-HT(3) receptors in mice could also be useful for prediction purposes.
机译：恶心和呕吐经常被视为许多药物的副作用，并可能导致不良的治疗依从性。在本研究中，我们旨在建立简单的方法来预测不呕吐的小鼠恶心和/或呕吐，使用已知会引起恶心和/或呕吐的药物和化学物质。使用胃肠道转运试验，通过酚红溶液排空液体胃（苯酚红方法）和通过树脂珠粒进行固体胃排空（珠子方法），以及抗痉挛剂（阿托品，0.1-3 mg / kg ip;鲑鱼降钙素） ，1-30单位/千克im，恶心剂（硫酸铜，1-30 mg / kg口服;阿扑吗啡，0.01-0.3 mg / kg sc）和化学治疗药（顺铂，0.3-10 mg / kg iv;阿霉素，0.3-评估10 mg / kg iv）。此外，还评估了5-羟色胺（5-HT）（3）受体拮抗剂ondansetron对鲑鱼降钙素，硫酸铜，顺铂和阿霉素诱导的固体胃排空的抑制作用。只有固体胃排空方法才能检测所有药物和化学药品的胃排空变化。我们还发现，由顺铂和阿霉素诱导的对固体胃排空的抑制被昂丹司琼剂量依赖性地拮抗。然而，恩丹西酮不能拮抗鲑鱼降钙素引起的延迟，但对硫酸铜的作用很小。在小鼠中，固体胃排空可能比胃肠道小肠运输或液体胃排空更合适，以预测恶心和/或呕吐。我们的结果还表明，化学治疗诱导的5-HT（3）受体介导的小鼠固体胃排空延迟也可用于预测目的。

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