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首页> 外文期刊>The Journal of toxicological sciences >S-mercuration of cellular proteins by methylmercury and its toxicological implications
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S-mercuration of cellular proteins by methylmercury and its toxicological implications

机译：甲基汞对细胞蛋白的S-硫化及其毒理学意义

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The accumulation of methylmercury (MeHg) through the daily consumption of large predatory fish poses potential health risks. MeHg has been found to cause Minamata disease, but the full nature of MeHg toxicity remains unclear. Because of its chemical properties, MeHg covalently binds to cellular proteins through their reactive thiols, referred to as S-mercuration, resulting in the formation of protein adducts. In this review, we summarize how the S-mercuration of cellular proteins could be involved in the major mechanisms that have been suggested to underlie MeHg toxicity. Additionally, we introduce our attempts to identify cases of S-mercuration for the research to reveal the true nature of MeHg toxicity.
机译：通过每天食用大型掠食性鱼类而积累的甲基汞（MeHg）构成潜在的健康风险。已发现甲基汞可引起水am病，但甲基汞毒性的全部性质仍不清楚。由于其化学性质，MeHg通过其反应性硫醇与细胞蛋白共价结合，称为S-汞化，导致形成蛋白质加合物。在这篇综述中，我们总结了细胞蛋白的S结合如何可能参与了MeHg毒性的主要机制。此外，我们介绍了为鉴定S-汞并购案例而进行的尝试，以揭示MeHg毒性的真实性质。

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