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首页> 外文期刊>The Journal of toxicological sciences >Adverse effect of sub-chronic exposure to benzo(a)pyrene and protective effect of butylated hydroxyanisole on learning and memory ability in male sprague-dawley rat
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Adverse effect of sub-chronic exposure to benzo(a)pyrene and protective effect of butylated hydroxyanisole on learning and memory ability in male sprague-dawley rat

机译：亚慢性暴露于苯并（a）re的不利影响和丁基羟基茴香醚对雄性sprague-dawley大鼠学习记忆的保护作用

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Previous studies demonstrate that benzo(a)pyrene (B(a)P) can affect hippocampal function and cause spatial cognition impairment. However, the mechanism is incomplete. Some evidence implies that B(a)P may cause an oxidative damage linking to the function of the hippocampus and antioxi-dant can prevent the oxidative damage in rats, but the ATPase and Ca2+ in the hippocampus and the protective effect of butylated hydroxyanisole (BHA) have not been studied. This study aimed to investigate the damage of toxicity further induced by B(a)P in hippocampus and the protective effect of BHA. Ninety-six male Sprague-Dawley (SD) rats were randomly divided into four groups (solvent control group, BHA-group, B(a)P-exposed group and B(a)P-BHA-combination group), with daily administration for 90 days. Morris water maze (MWM) was employed to evaluate the learning and memory ability. The levels of malonaldehyde (MDA) content, superoxide dismutase (SOD) activity, Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in hippocampus were measured by commercial kits. The concentration of Ca2+ in rat hippocampus was detected by fluorescent labeling. In behavior test it showed that there was an adverse effect on rats in the B(a)P -group. The levels of MDA content and Ca2+ content were significantly increased in the B(a)P group, while the activities of SOD and ATPase were significantly decreased. In the B(a)P-BHA group, the change of each index diminished significantly. The results suggested that the neurobehavioral toxicity of B(a)P might have a close relationship with oxidative damage, resulted in decreasing of ATPase activities and increasing of Ca2+ concentration in the hippocampus. Furthermore, BHA can prevent these damages.
机译：先前的研究表明，苯并（a）re（B（a）P）会影响海马功能并引起空间认知障碍。但是，该机制是不完整的。一些证据表明，B（a）P可能引起与海马功能相关的氧化损伤，抗氧化剂可以阻止大鼠的氧化损伤，但是海马中的ATPase和Ca2 +以及丁基化羟基茴香醚（BHA）的保护作用）尚未研究。这项研究旨在调查B（a）P进一步诱导的海马中毒的损害和BHA的保护作用。每天将96只雄性Sprague-Dawley（SD）大鼠随机分为四组（溶剂对照组，BHA组，B（a）P暴露组和B（a）P-BHA联合组）。持续90天。莫里斯水迷宫（MWM）被用来评估学习和记忆能力。用商业试剂盒测量海马中丙二醛（MDA）含量，超氧化物歧化酶（SOD）活性，Na + -K + -ATPase和Ca2 + -Mg2 + -ATPase的水平。通过荧光标记检测大鼠海马中Ca 2+的浓度。在行为测试中，它表明B（a）P-组对大鼠有不利影响。 B（a）P组的MDA含量和Ca2 +含量显着增加，而SOD和ATPase的活性则明显降低。在B（a）P-BHA组中，每个指标的变化均明显减少。结果表明，B（a）P的神经行为毒性可能与氧化损伤密切相关，导致海马中ATPase活性降低和Ca2 +浓度升高。此外，BHA可以防止这些损坏。

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